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Test Directory » Vasoactive Intestinal Polypeptide (VIP)

Vasoactive Intestinal Polypeptide (VIP)

Order Code: VASIPL

Test Summary

Vasoactive Intestinal Polypeptide (VIP) is a 28 amino acid multifunctional peptide that is involved in gastrointestinal, vasodilator, and neuroendocrine functions. VIP is derived from larger pro-molecules that often exhibit the same or greater immunogenicity than the native VIP. It is structurally related to PHIM, Glucagon, Secretin, Gastric Inhibitory Polypeptide, Corticotropin Releasing Factor and Growth Hormone-Releasing Hormone. VIP stimulates pituitary release of Prolactin, Growth Hormone and ACTH; stimulates Luteinizing Hormone-Releasing Hormone, Serotonin, gastric Somatostatin, Steroids and Renin. VIP inhibits the release of Gastrin, hypothalamic Somatostatin, and Histamine. VIP release is stimulated by cholinergic agonists, Atropine, Serotonin, Prostaglandins E1 and D2, and Nerve Growth Factor. VIP actions are inhibited by Corticosteroids, Dopamine and opiate agonists. Elevated levels of VIP are found in patients with VIPomas, hepatic cirrhosis, and the Verner-Morrison’s (Watery Diarrhea) Syndrome. Decreased levels are found in cystic fibrosis.

Aliases

  • N/A

Specimen Collection

Special Instructions

N/A

Preferred Specimen

1 mL Plasma collected in am EDTA (lavender top) tube, centrifuge, separate and freeze plasma as soon as possible.

Minimum Volume

0.5 mL

Instructions

Centrifuge lavender top (EDTA), transfer plasma to a plastic vial and freeze as soon as possible.

Patient Preparation

Patient should be fasting 10-12 hours prior to collection. Patient should not be on any antacid medication or medications that affect intestinal motility for a least 48 hours prior to collection.

Storage

Plastic screw-cap vial

Transport Temperature

Frozen

Specimen Stability

  • Room temperature: unacceptable
  • Refrigerated: 7 days
  • Frozen: 6 months

Limitations

N/A

Other Acceptable Specimens

N/A

Unacceptable Specimens

Gross hemolysis, gross lipemia, gross icterus

Order Code

VASIPL

EPIC (Premier) Code

LAB6898

Includes

N/A

CPT Code

  • 84586

Billing Code

  • 670041

CPT Statement

CPT Statement

Methodology

Direct Enzyme Immunoassay, Enzyme Linked Immunosorbent Assay

FDA Status

Not approved

Physician Attestation of Informed Consent

Not required

Testing Laboratory

Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153

Department

Reference Testing

Reference Range

Up to 36 pg/mL

Setup Schedule / Expected Turnaround Time

Monday - Friday; Report available: 3 - 5 business days

Specimen Collection

Special Instructions

N/A

Preferred Specimen

1 mL Plasma collected in am EDTA (lavender top) tube, centrifuge, separate and freeze plasma as soon as possible.

Minimum Volume

0.5 mL

Instructions

Centrifuge lavender top (EDTA), transfer plasma to a plastic vial and freeze as soon as possible.

Patient Preparation

Patient should be fasting 10-12 hours prior to collection. Patient should not be on any antacid medication or medications that affect intestinal motility for a least 48 hours prior to collection.

Storage

Plastic screw-cap vial

Transport Temperature

Frozen

Specimen Stability

  • Room temperature: unacceptable
  • Refrigerated: 7 days
  • Frozen: 6 months

Limitations

N/A

Other Acceptable Specimens

N/A

Unacceptable Specimens

Gross hemolysis, gross lipemia, gross icterus

Billing

CPT Code

  • 84586

Billing Code

  • 670041

CPT Statement

CPT Statement

Result Information

Methodology

Direct Enzyme Immunoassay, Enzyme Linked Immunosorbent Assay

Testing Laboratory

N/A

Reference Range

Up to 36 pg/mL

Setup Schedule / Expected Turnaround Time

Monday - Friday; Report available: 3 - 5 business days