Test Summary

Vasoactive Intestinal Polypeptide (VIP) is a 28 amino acid multifunctional peptide that is involved in gastrointestinal, vasodilator, and neuroendocrine functions. VIP is derived from larger pro-molecules that often exhibit the same or greater immunogenicity than the native VIP. It is structurally related to PHIM, Glucagon, Secretin, Gastric Inhibitory Polypeptide, Corticotropin Releasing Factor and Growth Hormone-Releasing Hormone. VIP stimulates pituitary release of Prolactin, Growth Hormone and ACTH; stimulates Luteinizing Hormone-Releasing Hormone, Serotonin, gastric Somatostatin, Steroids and Renin. VIP inhibits the release of Gastrin, hypothalamic Somatostatin, and Histamine. VIP release is stimulated by cholinergic agonists, Atropine, Serotonin, Prostaglandins E1 and D2, and Nerve Growth Factor. VIP actions are inhibited by Corticosteroids, Dopamine and opiate agonists. Elevated levels of VIP are found in patients with VIPomas, hepatic cirrhosis, and the Verner-Morrison’s (Watery Diarrhea) Syndrome. Decreased levels are found in cystic fibrosis.

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