Topiramate
Test Summary
Topiramate is an anticonvulsant used as an adjunctive treatment of partial-onset epilepsy. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity.
Aliases
- Topamax
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL serum collected in a red-top tube (no gel), or no additive (royal blue-top) tube, or plasma collected in a lithium heparin (green-top) tube
Minimum Volume
0.5 mL
Instructions
Draw at peak (2-4 hours after dose) or trough (0.5-1 hour before dose) at steady-state.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 7 days
- Refrigerated: 14 days
- Frozen: 30 days
Limitations
N/A
Other Acceptable Specimens
Plasma collected in a sodium heparin (green-top), or sodium heparin lead-free (tan-top) tube
Unacceptable Specimens
Gel barrier/serum separator tube
Order Code
TOPIRM
EPIC (Premier) Code
LAB1007
Includes
N/A
CPT Code
- 80201
Billing Code
- 700000
CPT Statement
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153
14225 Newbrook Drive
Chantilly VA, 20153
Reference Range
Therapeutic Range
| Dose (mg) | Peak (mcg/mL) | Trough (mcg/mL) |
| 100 | 6.5-9.2 | 4.5-6.6 |
| 200 | 12.0-16.0 | 8.0-12.0 |
| 400 | 20.0-30.0 | 14.0-20.0 |
Setup Schedule / Expected Turnaround Time
Monday - Saturday morning; Report available: 2 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL serum collected in a red-top tube (no gel), or no additive (royal blue-top) tube, or plasma collected in a lithium heparin (green-top) tube
Minimum Volume
0.5 mL
Instructions
Draw at peak (2-4 hours after dose) or trough (0.5-1 hour before dose) at steady-state.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 7 days
- Refrigerated: 14 days
- Frozen: 30 days
Limitations
N/A
Other Acceptable Specimens
Plasma collected in a sodium heparin (green-top), or sodium heparin lead-free (tan-top) tube
Unacceptable Specimens
Gel barrier/serum separator tube
Result Information
Methodology
Chromatography/Mass Spectrometry
Testing Laboratory
N/A
Reference Range
Therapeutic Range
| Dose (mg) | Peak (mcg/mL) | Trough (mcg/mL) |
| 100 | 6.5-9.2 | 4.5-6.6 |
| 200 | 12.0-16.0 | 8.0-12.0 |
| 400 | 20.0-30.0 | 14.0-20.0 |
Setup Schedule / Expected Turnaround Time
Monday - Saturday morning; Report available: 2 days