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Test Directory TSI (Thyroid Stimulating Immunoglobulin)

TSI (Thyroid Stimulating Immunoglobulin)

Test Summary

Graves' disease is a classic form of hyperthyroid disease, affecting approximately 0.4% of the population of the United States. It is caused by IgG immunoglobulins, collectively known as thyroid stimulating immunoglobulins (TSI). Patients who are candidates for antithyroid drug therapy may not respond to this treatment when TSI levels are markedly elevated. The determination of TSI can also assist in predicting hyperthyroidism in neonates, due to placental transmission of the immunoglobulins from a mother with hyperthyroidism.

Aliases

TSIG

Specimen Collection

Special Instructions

N/A

Preferred Specimen

1 mL serum

Minimum Volume

0.2 mL

Instructions

N/A

Patient Preparation

N/A

Storage

N/A

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 21 days
Frozen: 60 days

Limitations

N/A

Other Acceptable Specimens

N/A

Unacceptable Specimens

Gross hemolysis • Grossly lipemic • Grossly icteric • Plasma

Order Code

THYSI

EPIC (Premier) Code

LAB735

Includes

N/A

CPT Code

84445

Billing Code

700000

CPT Statement

Methodology

In Vitro Bioassay

FDA Status

FDA Approved

Physician Attestation of Informed Consent

N/A

Testing Laboratory

Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153

Reference Range

<140 % Baseline

Setup Schedule / Expected Turnaround Time

Monday - Saturday; Report available: 3 - 5 days