Thyroid Cancer (Thyroglobulin) Monitoring
Test Summary
Thyroglobulin measurements are most useful in the postoperative monitoring of patients with papillary, follicular, and Hurthle cell carcinomas. However, approximately 20% of individuals develop autoantibodies to thyroglobulin. Since these antibodies interfere with immunoassay measurement of thyroglobulin, it is necessary to determine the presence or absence of antibodies before measuring thyroglobulin. This panel provides a sensitive method for determination of thyroglobulin autoantibodies, with subsequent measurement of thyroglobulin by either a sensitive immunoassay (Tg Ab negative samples) or LCMSMS (Tg Ab positive samples). The mass spectrometry assay has no interference from autoantibodies.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
3 mL serum
Minimum Volume
1.5 mL
Instructions
Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.
Patient Preparation
N/A
Storage
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 6 days
- Refrigerated: 7 days
- Frozen: 28 days
Limitations
If Thyroglobulin Antibody is negative, then Thyroglobulin is tested on the Beckman Coulter DxI (CPT code: 84432). If Thyroglobulin Antibody is positive then, Thyroglobulin is tested by LC/MS/MS (CPT code: 84432).
Other Acceptable Specimens
N/A
Unacceptable Specimens
Hemolysis • Lipemia • Plasma • Icteric
Order Code
THYMON
EPIC (Premier) Code
LAB5385
Includes
If Thyroglobulin Antibody is negative, then Thyroglobulin is tested on the Beckman Coulter DxI (CPT code: 84432).
If Thyroglobulin Antibody is positive, then Thyroglobulin is tested by LC/MS/MS (CPT code: 84432).
If Thyroglobulin Antibody is positive, then Thyroglobulin is tested by LC/MS/MS (CPT code: 84432).
CPT Code
- 86800
Billing Code
- 670717
CPT Statement
Methodology
Immunoenzymatic
FDA Status
FDA Approved
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153
14225 Newbrook Drive
Chantilly VA, 20153
Department
Reference Testing
Reference Range
| Thyroglobulin Antibody | ≤1 IU/mL |
| Thyroglobulin | Athyrotic: <0.1 ng/mL |
| Thyroglobulin, LC/MS/MS | Athyrotic: <0.4 ng/mL |
Setup Schedule / Expected Turnaround Time
Tuesday - Sunday; Report available: 7 - 8 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
3 mL serum
Minimum Volume
1.5 mL
Instructions
Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.
Patient Preparation
N/A
Storage
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 6 days
- Refrigerated: 7 days
- Frozen: 28 days
Limitations
If Thyroglobulin Antibody is negative, then Thyroglobulin is tested on the Beckman Coulter DxI (CPT code: 84432). If Thyroglobulin Antibody is positive then, Thyroglobulin is tested by LC/MS/MS (CPT code: 84432).
Other Acceptable Specimens
N/A
Unacceptable Specimens
Hemolysis • Lipemia • Plasma • Icteric
Result Information
Methodology
Immunoenzymatic
Testing Laboratory
N/A
Reference Range
| Thyroglobulin Antibody | ≤1 IU/mL |
| Thyroglobulin | Athyrotic: <0.1 ng/mL |
| Thyroglobulin, LC/MS/MS | Athyrotic: <0.4 ng/mL |
Setup Schedule / Expected Turnaround Time
Tuesday - Sunday; Report available: 7 - 8 days