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Prostatic Acid Phosphatase (PAP)

Test Summary

High concentrations of acid phosphatase are found in the prostate gland. Significant amounts are also found in platelets, bone, spleen, kidney and liver. Prostatic Acid Phosphatase (PAP) is a component of total acid phosphates and is a major constituent in seminal fluid and is also secreted in the urine. PAP is normally found in serum in very low levels.
PAP measurement has found clinical application in the management of prostatic cancer patients. Serum PAP measurements have been useful in monitoring remission or relapse of a prostatic malignancy and in assessing the effectiveness of various treatment regimes. Thus, normalization in serum PAP levels has been observed following successful therapeutic intervention, while recurrent or residual disease has been associated with elevated levels of PAP.

Aliases

  • N/A

Specimen Collection

Special Instructions

N/A

Preferred Specimen

1 mL serum

Minimum Volume

0.5 mL

Instructions

Samples must be obtained before rectal examination, biopsy, prostatectomy or prostatic massage, since manipulating the prostate gland may lead to elevated PAP levels persisting up to 24-48 hours.
Specimens must be frozen if received by the laboratory greater than 24 hours after collection.

Patient Preparation

N/A

Storage

N/A

Transport Temperature

Frozen

Specimen Stability

  • Room temperature: 24 hours
  • Refrigerated: 24 hours
  • Frozen: 28 days

Limitations

Prostatic message, urinary catheter, rectal examination, and other physical contact with the prostate may cause elevated results.

Other Acceptable Specimens

N/A

Unacceptable Specimens

Gross hemolysis

Order Code

PRSPAP

EPIC (Premier) Code

LAB342

Includes

N/A

CPT Code

  • 84066

Billing Code

  • 670441

CPT Statement

CPT Statement

Methodology

Immunoassay (IA)

FDA Status

FDA Approved

Physician Attestation of Informed Consent

N/A

Testing Laboratory

Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153

Department

Reference Testing

Reference Range

Adult Male <2.8 ng/mL

Setup Schedule / Expected Turnaround Time

Monday - Saturday; Report available: 1 day

Specimen Collection

Special Instructions

N/A

Preferred Specimen

1 mL serum

Minimum Volume

0.5 mL

Instructions

Samples must be obtained before rectal examination, biopsy, prostatectomy or prostatic massage, since manipulating the prostate gland may lead to elevated PAP levels persisting up to 24-48 hours.
Specimens must be frozen if received by the laboratory greater than 24 hours after collection.

Patient Preparation

N/A

Storage

N/A

Transport Temperature

Frozen

Specimen Stability

  • Room temperature: 24 hours
  • Refrigerated: 24 hours
  • Frozen: 28 days

Limitations

Prostatic message, urinary catheter, rectal examination, and other physical contact with the prostate may cause elevated results.

Other Acceptable Specimens

N/A

Unacceptable Specimens

Gross hemolysis

Billing

CPT Code

  • 84066

Billing Code

  • 670441

CPT Statement

CPT Statement

Result Information

Methodology

Immunoassay (IA)

Testing Laboratory

N/A

Reference Range

Adult Male <2.8 ng/mL

Setup Schedule / Expected Turnaround Time

Monday - Saturday; Report available: 1 day