Schedule an Appointment Pay Bill View My Results

Test Directory

Test Directory » FISH, p53, Deletion 17p13.1

Test Directory FISH, p53, Deletion 17p13.1

FISH, p53, Deletion 17p13.1

Order Code: P53FSH

Test Summary

Loss of the p53 gene, located in chromosome 17p13.1, is a common occurrence in neoplastic disorders, including hematologic disorders. FISH studies for deletion p53 are performed in addition to G-banding analysis of bone marrow, hematologic blood, lymph nodes, and solid tumors. This probe may be useful in detecting loss of p53 in complex karyotypes. Deletion of p53 is an adverse prognostic marker in CLL and follicular lymphoma.

Aliases

Specimen Collection

Special Instructions

N/A

Preferred Specimen

3 mL bone marrow or 5 mL whole blood collected in sodium heparin (green-top) tube

Minimum Volume

1 mL bone marrow • 3 mL whole blood

Instructions

Clinical history/reason for referral is required with test order. Prior therapy and transplant history should be provided with test order.
Please specify if this test is run for plasma cell neoplasms.
Submit 1 to 3 mL of bone marrow or 3 to 5 mL whole blood in a sodium heparin (green-top) tube. Bone marrow transport medium is available upon request.

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Note: If results are not possible, the test order may be canceled and replaced with a Cytogenetics Communication.

Patient Preparation

N/A

Storage

N/A

Transport Temperature

Fresh lymph node: Refrigerated (cold packs)
All other specimens: Room temperature

Specimen Stability

Room temperature: See instructions
Refrigerated: See instructions
Frozen: See instructions

Limitations

N/A

Other Acceptable Specimens

Bone marrow or whole blood collected in: sodium heparin (royal blue-top) tube, or sodium heparin lead-free (tan-top) tube • Bone marrow submitted in culture transport media • 5x5mm fresh lymph node, or fresh biopsy in culture transport media

Unacceptable Specimens

N/A

Order Code

P53FSH

EPIC (Premier) Code

LAB6340

Includes

N/A

CPT Code

88271 (x2)
88275

Billing Code

670944
670945

CPT Statement

Methodology

Fluorescence In Situ Hybridization (FISH)

FDA Status

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Physician Attestation of Informed Consent

N/A

Testing Laboratory

Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153

Department

Reference Testing

Reference Range

See Laboratory Report

Setup Schedule / Expected Turnaround Time

Monday - Sunday morning; Report available: 5 days