Myelin Basic Protein
Test Summary
The concentration of MBP is often increased in patients with demyelinating diseases such as multiple sclerosis and may be increased in patients with head injury, CNS trauma, tumor, stroke, and viral encephalitis.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1.2 mL CSF collected in a sterile CSF collection tube #4
Minimum Volume
0.5 mL
Instructions
Do not centrifuge CSF. Refrigerate CSF and send refrigerated (cold packs) or freeze CSF specimens -20 degrees C or lower and send frozen samples on dry ice to the laboratory.
Blood contamination and hemolysis may interfere with results. CSF must be clear. Submitting 4th lumbar puncture collection tube minimizes blood contamination.
Blood contamination and hemolysis may interfere with results. CSF must be clear. Submitting 4th lumbar puncture collection tube minimizes blood contamination.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Frozen
Specimen Stability
- Room temperature 7 days
- Refrigerated 14 days
- Frozen 21 days
Limitations
The presence of myelin basic protein in the spinal fluid is supportive evidence for the diagnosis of multiple sclerosis and other demyelinating diseases, although it is a non-specific finding and present in other causes of damage to CNS myelin.
Other Acceptable Specimens
N/A
Unacceptable Specimens
xanthochromia/RBCs/hemolysis in CSF
Order Code
MBP
EPIC (Premier) Code
LAB307
Includes
N/A
CPT Code
- 83873
Billing Code
- 670158
CPT Statement
Methodology
Radioimmunoassay (RIA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153
14225 Newbrook Drive
Chantilly VA, 20153
Department
Reference Testing
Reference Range
| ≤4.0 mcg/L | Negative |
| 4.1-6.0 mcg/L | Weakly positive |
| >6.0 mcg/L | Positive |
Setup Schedule / Expected Turnaround Time
Monday, Thursday; Reports available: 3 - 7 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1.2 mL CSF collected in a sterile CSF collection tube #4
Minimum Volume
0.5 mL
Instructions
Do not centrifuge CSF. Refrigerate CSF and send refrigerated (cold packs) or freeze CSF specimens -20 degrees C or lower and send frozen samples on dry ice to the laboratory.
Blood contamination and hemolysis may interfere with results. CSF must be clear. Submitting 4th lumbar puncture collection tube minimizes blood contamination.
Blood contamination and hemolysis may interfere with results. CSF must be clear. Submitting 4th lumbar puncture collection tube minimizes blood contamination.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Frozen
Specimen Stability
- Room temperature 7 days
- Refrigerated 14 days
- Frozen 21 days
Limitations
The presence of myelin basic protein in the spinal fluid is supportive evidence for the diagnosis of multiple sclerosis and other demyelinating diseases, although it is a non-specific finding and present in other causes of damage to CNS myelin.
Other Acceptable Specimens
N/A
Unacceptable Specimens
xanthochromia/RBCs/hemolysis in CSF
Result Information
Methodology
Radioimmunoassay (RIA)
Testing Laboratory
N/A
Reference Range
| ≤4.0 mcg/L | Negative |
| 4.1-6.0 mcg/L | Weakly positive |
| >6.0 mcg/L | Positive |
Setup Schedule / Expected Turnaround Time
Monday, Thursday; Reports available: 3 - 7 days