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Test Directory » FISH, MALT Lymphoma, MALT1, rea18q21 with Reflex to API2/MALT1, t(11;18)

Test Directory FISH, MALT Lymphoma, MALT1, rea18q21 with Reflex to API2/MALT1, t(11;18)

FISH, MALT Lymphoma, MALT1, rea18q21 with Reflex to API2/MALT1, t(11;18)

Order Code: MALT1

Test Summary

The extra-nodal marginal zone B-cell lymphoma (MZBCL) of mucosa associated lymphoid tissue (MALT) type, which comprises 7% of all non-Hodgkin lymphomas, is an indolent disease, involving most often the stomach, where it usually follows chronic gastritis, due to Helicobacter pylori (HP) infection. This lymphoma may also localize in the lung, the thyroid, the salivary gland, and the orbit. Two common translocations in this lymphoma are the t(11;18)(q12;q21) (20-50% of cases) and the t(14;18) (q32;q21) (10-20% of cases). This break apart 18q21 probe is able to detect either of these translocations. It is suggested to follow up a positive FISH result with the specific dual-fusion API2/MALT1 probe to detect the presence of the translocation (11;18) since this is often associated with resistance to HP treatment.

Aliases

Specimen Collection

Special Instructions

N/A

Preferred Specimen

5 mL whole blood collected in a sodium heparin (green-top) tube, or
3 mL bone marrow collected in a sodium heparin (green-top) tube

Minimum Volume

1 mL

Instructions

For bone marrow (1-3 mL) or whole blood (3-5 mL) use green top (sodium heparin) tube. For lymph node biopsy 5x5 mm in a sterile container in Hank's Ringer's solution or culture medium with antibiotics. Transportation medium available upon request. Formalin fixed paraffin embedded tissue.

Patient Preparation

N/A

Storage

N/A

Transport Temperature

Room temperature

Specimen Stability

Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Limitations

N/A

Other Acceptable Specimens

Formalin-fixed, paraffin-embedded tissue • 5x5 mm lymph node tissue or lymph node collected in a sterile container

Unacceptable Specimens

N/A

Order Code

MALT1

EPIC (Premier) Code

N/A

Includes

If FISH, MALT Lymphoma, MALT1, rea18q21 is positive, then FISH, MALT Lymphoma, API2/MALT1, t(11;18) will be performed at an additional charge (CPT code(s): 88271 (x2), 88275),

CPT Code

88271 (x2)
88275

Billing Code

671072
671073

CPT Statement

Methodology

Fluorescence In Situ Hybridization (FISH)

FDA Status

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Physician Attestation of Informed Consent

N/A

Testing Laboratory

Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153

Department

Reference Testing

Reference Range

See Laboratory Report

Setup Schedule / Expected Turnaround Time

Monday-Saturday; Report available: N/A