Lysozyme (Muramidase)
Test Summary
Lysozyme in the serum is primarily due to the degradation of granulocytes and monocytes and its concentration reflects the turnover of these cells. Increases are seen in benign and malignant processes. Serum lysozyme is elevated in patients with acute or chronic granulocytic or monocytic leukemias and levels decrease with successful treatment. Conversely, patients with lymphocytic leukemia may have depressed plasma lysozyme levels.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Instructions
Centrifuge serum specimens within 1 hour of collection. Transfer serum to sterile, plastic, screw-cap vial. Delayed separation of the serum can result in spuriously high levels of lysozyme, presumably because of the breakdown of leukocytes.
Patient Preparation
N/A
Storage
Plastic screw-cap vial
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: 24 hours
- Refrigerated: 15 days
- Frozen: 18 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
Room temperature samples older than 24 hours • Plasma collected in citrate or heparin • Moderate to gross hemolysis • Grossly lipemic
Order Code
LYSOZM
EPIC (Premier) Code
LAB640
Includes
N/A
CPT Code
- 85549
Billing Code
- 700000
CPT Statement
Methodology
Enzymatic
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153
14225 Newbrook Drive
Chantilly VA, 20153
Reference Range
5.0-11.0 mcg/mL
Setup Schedule / Expected Turnaround Time
Monday - Saturday morning; Report available: Next day
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Instructions
Centrifuge serum specimens within 1 hour of collection. Transfer serum to sterile, plastic, screw-cap vial. Delayed separation of the serum can result in spuriously high levels of lysozyme, presumably because of the breakdown of leukocytes.
Patient Preparation
N/A
Storage
Plastic screw-cap vial
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: 24 hours
- Refrigerated: 15 days
- Frozen: 18 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
Room temperature samples older than 24 hours • Plasma collected in citrate or heparin • Moderate to gross hemolysis • Grossly lipemic
Result Information
Methodology
Enzymatic
Testing Laboratory
N/A
Reference Range
5.0-11.0 mcg/mL
Setup Schedule / Expected Turnaround Time
Monday - Saturday morning; Report available: Next day