Test Summary

This panel may be ordered to assist in the initial diagnosis and subsequent management of inflammatory, infectious, autoimmune, neoplastic, or other immune-mediated disorders affecting the nervous system. Quantitative values for IgM, IgG, and IgA will be reported [1].

Immunoglobulins, or antibodies, are proteins made by the immune system in response to an infection or other potential threat. Immunoglobulins come in various forms (IgM, IgG, IgA, and others) and have unique properties and functions to coordinate the bodys response [1].

A serum-based immunoglobulin panel (test code 7083) can also be used to evaluate conditions associated with abnormal immunoglobulin levels; however, this test, which uses CSF as the sample is preferred if there is clinical suspicion of multiple sclerosis (MS). About 80% of patients with MS have elevated IgG antibody levels in their CSF, making this test useful for diagnosis [2].

This test should be interpreted in the context of pertinent clinical and family history and physical examination findings.

References
1. Burtis C, et al. Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics. St Louis, Missouri: Elsevier; 2015:310-314.
2. National Institutes of Health. CSF immunoglobulins G (IgG) index. https://medlineplus.gov/lab-tests/csf-immunoglobulin-g-igg-index/. Last updated June 27, 2018. Accessed January 14, 2020.

Aliases

Specimen Collection

Special Instructions

Preferred Specimen

Minimum Volume

Instructions

Patient Preparation

Storage

Transport Temperature

Specimen Stability

Limitations

Other Acceptable Specimens

Unacceptable Specimens

Order Code

EPIC (Premier) Code

Includes

CPT Code

Billing Code

CPT Statement

Methodology

FDA Status

Physician Attestation of Informed Consent

Testing Laboratory

Department

Reference Range

Setup Schedule / Expected Turnaround Time