FISH, Multiple Myeloma, IGH/MAFB, t(14;20)
Test Summary
The IGH-MAFB probe set is used to detect the t(14;20)(q32;q12) in patients with high-risk plasma cell myeloma (PCM).
This translocation is strongly associated with del(13q), hypodiploidy, and gain of 1q. However, patients with t(14;20) and monoclonal gammopathy, MGUS, or smoldering PCM, may have stable disease for years before progressing.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
3 mL bone marrow submitted in culture transport media
Minimum Volume
1 mL
Instructions
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: See Collection Instructions
- Refrigerated: See Collection Instructions
- Frozen: See Collection Instructions
Limitations
N/A
Other Acceptable Specimens
Bone marrow collected in: Sodium heparin (green-top) tube, sodium heparin (royal blue-top) tube, or sodium heparin lead-free (tan-top) tube
Unacceptable Specimens
N/A
Order Code
IGHM
EPIC (Premier) Code
LAB5354
Includes
N/A
CPT Code
- 88275
- 88271 (x2) - **Please note: Test is restricted to bone marrow specimens for New York patient testing**
Billing Code
- 670096
- 670097
CPT Statement
Methodology
Fluorescence In Situ Hybridization (FISH)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153
14225 Newbrook Drive
Chantilly VA, 20153
Department
Reference Testing
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Daily; Report available: 6 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
3 mL bone marrow submitted in culture transport media
Minimum Volume
1 mL
Instructions
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: See Collection Instructions
- Refrigerated: See Collection Instructions
- Frozen: See Collection Instructions
Limitations
N/A
Other Acceptable Specimens
Bone marrow collected in: Sodium heparin (green-top) tube, sodium heparin (royal blue-top) tube, or sodium heparin lead-free (tan-top) tube
Unacceptable Specimens
N/A
Billing
CPT Code
- 88275
- 88271 (x2) - **Please note: Test is restricted to bone marrow specimens for New York patient testing**
Billing Code
- 670096
- 670097
CPT Statement
Result Information
Methodology
Fluorescence In Situ Hybridization (FISH)
Testing Laboratory
N/A
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Daily; Report available: 6 days