Glutamic Acid Decarboxylase-65 Antibody
Order Code:
GLUTAM
Test Summary
Glutamic Acid Decarboxylase (GAD65) Antibody is useful to diagnose insulin dependent diabetes mellitus [Type I diabetes (autoimmune mediated diabetes)] to assess risk for development of Type I diabetes, to predict onset of Type I diabetes, and risk of development of related endocrine disorders, e.g., thyroiditis. Before clinical onset, Type I diabetes is characterized by lymphocytic infiltration of the islet cells, and by circulating autoantibodies against a variety of islet cell antigens, including GAD-65, IA-2 (a tyrosine phosphatase-like protein), and insulin (IAA).
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Instructions
N/A
Patient Preparation
N/A
Storage
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 7 days
- Refrigerated: 14 days
- Frozen: 60 days
Limitations
GAD-65 antibodies are detected in 20% of diabetic twins who remain disease-free for long periods of time and in 8% of healthy individuals.
Other Acceptable Specimens
N/A
Unacceptable Specimens
N/A
Order Code
GLUTAM
EPIC (Premier) Code
LAB586
Includes
N/A
CPT Code
- 86341
Billing Code
- 670027
CPT Statement
Methodology
Enzyme Linked Immunosorbent Assay (ELISA)
FDA Status
FDA Approved
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153
14225 Newbrook Drive
Chantilly VA, 20153
Department
Reference Testing
Reference Range
<5 IU/mL
Setup Schedule / Expected Turnaround Time
Sunday - Friday evening; Report available: 3 - 5 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Instructions
N/A
Patient Preparation
N/A
Storage
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 7 days
- Refrigerated: 14 days
- Frozen: 60 days
Limitations
GAD-65 antibodies are detected in 20% of diabetic twins who remain disease-free for long periods of time and in 8% of healthy individuals.
Other Acceptable Specimens
N/A
Unacceptable Specimens
N/A
Result Information
Methodology
Enzyme Linked Immunosorbent Assay (ELISA)
Testing Laboratory
N/A
Reference Range
<5 IU/mL
Setup Schedule / Expected Turnaround Time
Sunday - Friday evening; Report available: 3 - 5 days