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FISH, Locus-specific Probe (x2)

Test Summary

This FISH (fluorescence in situ hybridization) assay is performed using any combination of two probes.

Aliases

  • N/A

Specimen Collection

Special Instructions

N/A

Preferred Specimen

5 mL whole blood collected in a sodium heparin (green-top or royal blue-top or tan-top) tube or
3 mL bone marrow collected in a sodium heparin (green-top or royal blue-top or tan-top) tube or
5 mL amniotic fluid collected in a sterile container or
5 mg CVS collected in culture media or
5x5 mm fresh tissue collected in a sterile container or Formalin Fixed Paraffin Embedded Tissue

Minimum Volume

1 mL whole blood • 1 mL bone marrow • 5 mL amniotic fluid • 5 mg CVS

Instructions

Clinical history/reason for referral is required with test order. Prior therapy and transplant history should be provided with test order.
Specimen requirements: 3-5 mL Whole blood or bone marrow collected in sodium heparin tube, 5 mL Amniotic fluid collected in sterile container, 5 mg CVS in culture media, 5X5 mm Fresh tissue in sterile container, Formalin Fixed Paraffin Embedded Tissue.

Specimen viability decreases during transit. Send specimen to testing laboratory for viability determination. Do not freeze. Do not reject.

Patient Preparation

N/A

Storage

See preferred specimen requirements

Transport Temperature

Room temperature

Specimen Stability

  • Room temperature: See instructions
  • Refrigerated: See instructions
  • Frozen: See instructions

Limitations

N/A

Other Acceptable Specimens

N/A

Unacceptable Specimens

N/A

Order Code

FSHLS2

EPIC (Premier) Code

LAB6338

Includes

This test code is for ordering interphase fluorescence in situ hybridization (FISH) analysis of 100-300 cells using two probes. The locus for the probes must be identified with the order. Please call laboratory before sample submission for availability of probes.

This test is performed in addition to G-banding chromosome analysis. Submit appropriate specimen as required for conventional cytogenetic analysis (amniotic fluid, whole blood, bone marrow, or tissue).

If one or more FISH tests are ordered on a specimen without chromosome analysis, a tissue culture test code will be added at an additional charge.
If results are not possible, the test order may be canceled and replaced with a Cytogenetics Communication.

CPT Code

  • 88271 (x2)
  • 88275

Billing Code

  • 670307
  • 670308

CPT Statement

Methodology

Fluorescence In Situ Hybridization (FISH)

FDA Status

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Physician Attestation of Informed Consent

N/A

Testing Laboratory

Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153

Department

Reference Testing

Reference Range

See Laboratory Report

Setup Schedule / Expected Turnaround Time

Daily; Report available: 5 days

Specimen Collection

Special Instructions

N/A

Preferred Specimen

5 mL whole blood collected in a sodium heparin (green-top or royal blue-top or tan-top) tube or
3 mL bone marrow collected in a sodium heparin (green-top or royal blue-top or tan-top) tube or
5 mL amniotic fluid collected in a sterile container or
5 mg CVS collected in culture media or
5x5 mm fresh tissue collected in a sterile container or Formalin Fixed Paraffin Embedded Tissue

Minimum Volume

1 mL whole blood • 1 mL bone marrow • 5 mL amniotic fluid • 5 mg CVS

Instructions

Clinical history/reason for referral is required with test order. Prior therapy and transplant history should be provided with test order.
Specimen requirements: 3-5 mL Whole blood or bone marrow collected in sodium heparin tube, 5 mL Amniotic fluid collected in sterile container, 5 mg CVS in culture media, 5X5 mm Fresh tissue in sterile container, Formalin Fixed Paraffin Embedded Tissue.

Specimen viability decreases during transit. Send specimen to testing laboratory for viability determination. Do not freeze. Do not reject.

Patient Preparation

N/A

Storage

See preferred specimen requirements

Transport Temperature

Room temperature

Specimen Stability

  • Room temperature: See instructions
  • Refrigerated: See instructions
  • Frozen: See instructions

Limitations

N/A

Other Acceptable Specimens

N/A

Unacceptable Specimens

N/A

Billing

CPT Code

  • 88271 (x2)
  • 88275

Billing Code

  • 670307
  • 670308

CPT Statement

Result Information

Methodology

Fluorescence In Situ Hybridization (FISH)

Testing Laboratory

N/A

Reference Range

See Laboratory Report

Setup Schedule / Expected Turnaround Time

Daily; Report available: 5 days