FISH, B-Cell Chronic Lymphocytic Leukemia Panel
Order Code:
FSHBCL
Test Summary
This test is performed to detect the rearrangements of 6q21 (SEC63), 6q23 (MYB), ATM (11q22.3), centromere 12 (D12Z3), 13q14.3 (DLEU), 13q34 (LAMP1) and TP53 (17p13.1) regions, by FISH (fluorescence in situ hybridization). This assay is useful for prognostic assessment for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL).
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
3 mL bone marrow or 5 mL whole blood collected a sodium heparin (green-top) tube
Minimum Volume
1 mL bone marrow • 3 mL whole blood
Instructions
Clinical history and reason for referral are required with test order. Prior therapy and transplant history should be provided with test order.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Note: If results are not possible, the test order may be canceled and replaced with a Cytogenetics Communication.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Note: If results are not possible, the test order may be canceled and replaced with a Cytogenetics Communication.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: See Collection Instructions
- Refrigerated: See Collection Instructions
- Frozen: See Collection Instructions
Limitations
N/A
Other Acceptable Specimens
Bone marrow or whole blood collected in: Sodium heparin (royal blue-top) tube or sodium heparin lead-free (tan-top) tube • 5x5mm lymph node tissue collected in Culture Transport Medium
Unacceptable Specimens
N/A
Order Code
FSHBCL
EPIC (Premier) Code
LAB5250
Includes
N/A
CPT Code
- 88271 (x6)
- 88275 (x3)
Billing Code
- 671060
- 671061
CPT Statement
Methodology
Fluorescence In Situ Hybridization (FISH)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153
14225 Newbrook Drive
Chantilly VA, 20153
Department
Reference Testing
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Daily; Report available: 8 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
3 mL bone marrow or 5 mL whole blood collected a sodium heparin (green-top) tube
Minimum Volume
1 mL bone marrow • 3 mL whole blood
Instructions
Clinical history and reason for referral are required with test order. Prior therapy and transplant history should be provided with test order.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Note: If results are not possible, the test order may be canceled and replaced with a Cytogenetics Communication.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Note: If results are not possible, the test order may be canceled and replaced with a Cytogenetics Communication.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: See Collection Instructions
- Refrigerated: See Collection Instructions
- Frozen: See Collection Instructions
Limitations
N/A
Other Acceptable Specimens
Bone marrow or whole blood collected in: Sodium heparin (royal blue-top) tube or sodium heparin lead-free (tan-top) tube • 5x5mm lymph node tissue collected in Culture Transport Medium
Unacceptable Specimens
N/A
Result Information
Methodology
Fluorescence In Situ Hybridization (FISH)
Testing Laboratory
N/A
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Daily; Report available: 8 days