Coccidioides Antibody, Complement Fixation, CSF
Test Summary
Infection by Coccidioides immitis can produce a spectrum of disease with most patients being asymptomatic and some developing disseminated disease including pneumonia and meningitis. C. immitis meningitis is associated with a mononuclear pleocytosis.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL CSF collected in a sterile plastic leak-proof CSF container
Minimum Volume
0.2 mL
Instructions
N/A
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 7 days
- Refrigerated: 14 days
- Frozen: 30 days
Limitations
False-negatives may occur in patients with solitary pulmonary lesions. Patients with active histoplasmosis may generate cross reactions. Elevated serum antibodies may be present in patients with meningeal coccidiocomycosis.
Other Acceptable Specimens
N/A
Unacceptable Specimens
Gross hemolysis • Grossly icteric
Order Code
COCCD
EPIC (Premier) Code
LAB3562
Includes
N/A
CPT Code
- 86635
Billing Code
- 670219
CPT Statement
Methodology
Complement Fixation (CF)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153
14225 Newbrook Drive
Chantilly VA, 20153
Department
Reference Testing
Reference Range
<1:1 titer
Interpretive Criteria| <1:1 | Antibody Not Detected |
| ≥1:1 | Antibody Detected |
Setup Schedule / Expected Turnaround Time
Tuesday - Saturday; Report available: 2 - 5 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL CSF collected in a sterile plastic leak-proof CSF container
Minimum Volume
0.2 mL
Instructions
N/A
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 7 days
- Refrigerated: 14 days
- Frozen: 30 days
Limitations
False-negatives may occur in patients with solitary pulmonary lesions. Patients with active histoplasmosis may generate cross reactions. Elevated serum antibodies may be present in patients with meningeal coccidiocomycosis.
Other Acceptable Specimens
N/A
Unacceptable Specimens
Gross hemolysis • Grossly icteric
Result Information
Methodology
Complement Fixation (CF)
Testing Laboratory
N/A
Reference Range
<1:1 titer
Interpretive Criteria| <1:1 | Antibody Not Detected |
| ≥1:1 | Antibody Detected |
Setup Schedule / Expected Turnaround Time
Tuesday - Saturday; Report available: 2 - 5 days