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Test Directory Clomipramine

Clomipramine

Order Code: CLOMIP

Test Summary

Clomipramine and its active metabolite, norclomipramine are antidepressant drugs. Therapeutic drug monitoring is useful to optimize dose and to avoid toxicity.

Aliases

Specimen Collection

Special Instructions

N/A

Preferred Specimen

3 mL serum collected in a red-top tube (no gel)

Minimum Volume

1.5 mL

Instructions

N/A

Patient Preparation

Collect at steady-state trough concentration. Specimen should be collected >12 hours after dose.

Storage

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 8 hours
Refrigerated: 5 days
Frozen: 30 days

Limitations

N/A

Other Acceptable Specimens

Plasma collected in: EDTA (lavender-top) tube, sodium heparin (green-top) tube, or lithium heparin (green-top) tube

Unacceptable Specimens

Gross hemolysis • Gel barrier/Serum separator tube (SST)

Order Code

CLOMIP

EPIC (Premier) Code

LAB802

Includes

Clomipramine, Desmethylclomipramine and Total

CPT Code

80299

Billing Code

671332

CPT Statement

Methodology

Chromatography/Mass Spectrometry

FDA Status

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Physician Attestation of Informed Consent

N/A

Testing Laboratory

Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153

Department

Reference Testing

Reference Range

Clomipramine	50-250 mcg/L
Desmethylclomipramine	150-350 mcg/L
Total	200-600 mcg/L

Setup Schedule / Expected Turnaround Time

Monday - Saturday; Report available: 1 day