Bladder Cancer, FISH
Order Code:
BLADDR
Test Summary
UroVysion® FISH, detects aneuploidy of chromosomes 3,7,17 and loss of 9p21 locus. Useful for monitoring bladder cancer and in the initial diagnosis of bladder cancer in patients with hematuria.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
50 mL voided urine collected in PreservCyt®
Minimum Volume
33 mL
Instructions
Urine (preferred): A urine preservative transport kit, with handling instructions, is available upon request. Perform urine collection (50 mL) at the physician's office or Patient Service Center (PSC) in a sterile 100 mL urine specimen container. Mix voided urine with CytoLyt® or ethanol 50% in a 1:1 solution. Alternatively, mix urine with preservative Carbowax™ (2% polyethylene glycol in 50% ethanol) 2:1 (v:v).
Bladder washings (acceptable): Perform bladder washing collection (50 mL) at the physician's office in a sterile 100 mL urine specimen container. Mix bladder washing with CytoLyt® or ethanol 50% in a 1:1 solution. Alternatively, mix bladder washing with preservative Carbowax™ (2% polyethylene glycol in 50% ethanol) 2:1(v:v).
It is recommended that specimens be processed within 72 hours of collection. Samples received without preservative will be assayed; any study under these conditions yielding insufficient cells or an abnormal result should have a follow-up study with urine in a preservative. Cold packs are recommended during transportation. If bladder washing is not shipped immediately after collection, refrigerate immediately (DO NOT FREEZE). Under no circumstances should bladder-washing specimens be stored or shipped at temperatures at or above 37°C.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not reject. Do not freeze.
Bladder washings (acceptable): Perform bladder washing collection (50 mL) at the physician's office in a sterile 100 mL urine specimen container. Mix bladder washing with CytoLyt® or ethanol 50% in a 1:1 solution. Alternatively, mix bladder washing with preservative Carbowax™ (2% polyethylene glycol in 50% ethanol) 2:1(v:v).
It is recommended that specimens be processed within 72 hours of collection. Samples received without preservative will be assayed; any study under these conditions yielding insufficient cells or an abnormal result should have a follow-up study with urine in a preservative. Cold packs are recommended during transportation. If bladder washing is not shipped immediately after collection, refrigerate immediately (DO NOT FREEZE). Under no circumstances should bladder-washing specimens be stored or shipped at temperatures at or above 37°C.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not reject. Do not freeze.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: See instructions
- Refrigerated: See instructions
- Frozen: See instructions
Limitations
N/A
Other Acceptable Specimens
Bladder washing collected in a sterile leak-proof PreservCyt®
Unacceptable Specimens
N/A
Order Code
BLADDR
EPIC (Premier) Code
LAB3036
Includes
N/A
CPT Code
- 88121
Billing Code
- 670953
CPT Statement
Methodology
Fluorescence In Situ Hybridization (FISH)
FDA Status
The analytical performance characteristics of this assay have been determined by Quest Diagnostics Nichols Institute. The modifications have not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153
14225 Newbrook Drive
Chantilly VA, 20153
Department
Reference Testing
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Daily; Report available: 4 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
50 mL voided urine collected in PreservCyt®
Minimum Volume
33 mL
Instructions
Urine (preferred): A urine preservative transport kit, with handling instructions, is available upon request. Perform urine collection (50 mL) at the physician's office or Patient Service Center (PSC) in a sterile 100 mL urine specimen container. Mix voided urine with CytoLyt® or ethanol 50% in a 1:1 solution. Alternatively, mix urine with preservative Carbowax™ (2% polyethylene glycol in 50% ethanol) 2:1 (v:v).
Bladder washings (acceptable): Perform bladder washing collection (50 mL) at the physician's office in a sterile 100 mL urine specimen container. Mix bladder washing with CytoLyt® or ethanol 50% in a 1:1 solution. Alternatively, mix bladder washing with preservative Carbowax™ (2% polyethylene glycol in 50% ethanol) 2:1(v:v).
It is recommended that specimens be processed within 72 hours of collection. Samples received without preservative will be assayed; any study under these conditions yielding insufficient cells or an abnormal result should have a follow-up study with urine in a preservative. Cold packs are recommended during transportation. If bladder washing is not shipped immediately after collection, refrigerate immediately (DO NOT FREEZE). Under no circumstances should bladder-washing specimens be stored or shipped at temperatures at or above 37°C.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not reject. Do not freeze.
Bladder washings (acceptable): Perform bladder washing collection (50 mL) at the physician's office in a sterile 100 mL urine specimen container. Mix bladder washing with CytoLyt® or ethanol 50% in a 1:1 solution. Alternatively, mix bladder washing with preservative Carbowax™ (2% polyethylene glycol in 50% ethanol) 2:1(v:v).
It is recommended that specimens be processed within 72 hours of collection. Samples received without preservative will be assayed; any study under these conditions yielding insufficient cells or an abnormal result should have a follow-up study with urine in a preservative. Cold packs are recommended during transportation. If bladder washing is not shipped immediately after collection, refrigerate immediately (DO NOT FREEZE). Under no circumstances should bladder-washing specimens be stored or shipped at temperatures at or above 37°C.
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not reject. Do not freeze.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: See instructions
- Refrigerated: See instructions
- Frozen: See instructions
Limitations
N/A
Other Acceptable Specimens
Bladder washing collected in a sterile leak-proof PreservCyt®
Unacceptable Specimens
N/A
Result Information
Methodology
Fluorescence In Situ Hybridization (FISH)
Testing Laboratory
N/A
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Daily; Report available: 4 days