Beta-2 Transferrin
Order Code:
B2TRAN
Test Summary
Presence of Beta-2 Transferrin (B2T) in nose and ear secretions is indicative of cerebrospinal fluid (CSF) leakage. B2T is used as a marker of CSF leakage for the diagnosis of rhinorrhea or otorrhea as a result of head trauma, tumor, congenital malformation, surgery etc. Prompt diagnosis and localization helps localization and life-threatening CNS infections.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
0.5 mL body fluid collected in a sterile, plastic, leak-proof transport tube
Minimum Volume
0.2 mL
Instructions
• Indicate specimen source
• If direct collection is not feasible, specimen may be collected using plain cotton swab and submitted in a sterile, plastic leak-proof transport tube.
• If submitting syringe, remove needle and cap the syringe to avoid specimen leakage.
• Do not collect specimen with a culture swab.
• Do not add any liquid to the swab.
Additional Information
• Specimens contaminated with salivary fluid degrade the beta-2 transferrin. These specimens should be frozen immediately following collection and should be kept frozen until testing is performed.
• Specimens collected with additives yield uninterpretable results and will be rejected.
• If direct collection is not feasible, specimen may be collected using plain cotton swab and submitted in a sterile, plastic leak-proof transport tube.
• If submitting syringe, remove needle and cap the syringe to avoid specimen leakage.
• Do not collect specimen with a culture swab.
• Do not add any liquid to the swab.
Additional Information
• Specimens contaminated with salivary fluid degrade the beta-2 transferrin. These specimens should be frozen immediately following collection and should be kept frozen until testing is performed.
• Specimens collected with additives yield uninterpretable results and will be rejected.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 15 days
- Refrigerated: 30 days
- Frozen: 60 days
Limitations
N/A
Other Acceptable Specimens
See Collection Instructions
Unacceptable Specimens
Specimens collected with additives
Order Code
B2TRAN
EPIC (Premier) Code
LAB3064
Includes
N/A
CPT Code
- 86335
Billing Code
- 670573
CPT Statement
Methodology
Electrophoresis • Immunofixation
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153
14225 Newbrook Drive
Chantilly VA, 20153
Department
Reference Testing
Reference Range
Not detected
Setup Schedule / Expected Turnaround Time
Daily; Report available: 1 - 2 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
0.5 mL body fluid collected in a sterile, plastic, leak-proof transport tube
Minimum Volume
0.2 mL
Instructions
• Indicate specimen source
• If direct collection is not feasible, specimen may be collected using plain cotton swab and submitted in a sterile, plastic leak-proof transport tube.
• If submitting syringe, remove needle and cap the syringe to avoid specimen leakage.
• Do not collect specimen with a culture swab.
• Do not add any liquid to the swab.
Additional Information
• Specimens contaminated with salivary fluid degrade the beta-2 transferrin. These specimens should be frozen immediately following collection and should be kept frozen until testing is performed.
• Specimens collected with additives yield uninterpretable results and will be rejected.
• If direct collection is not feasible, specimen may be collected using plain cotton swab and submitted in a sterile, plastic leak-proof transport tube.
• If submitting syringe, remove needle and cap the syringe to avoid specimen leakage.
• Do not collect specimen with a culture swab.
• Do not add any liquid to the swab.
Additional Information
• Specimens contaminated with salivary fluid degrade the beta-2 transferrin. These specimens should be frozen immediately following collection and should be kept frozen until testing is performed.
• Specimens collected with additives yield uninterpretable results and will be rejected.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 15 days
- Refrigerated: 30 days
- Frozen: 60 days
Limitations
N/A
Other Acceptable Specimens
See Collection Instructions
Unacceptable Specimens
Specimens collected with additives
Result Information
Methodology
Electrophoresis • Immunofixation
Testing Laboratory
N/A
Reference Range
Not detected
Setup Schedule / Expected Turnaround Time
Daily; Report available: 1 - 2 days