Aldosterone/Plasma Renin Activity Ratio, LC/MS/MS
Test Summary
The Aldosterone-renin ratio is used to screen for primary aldosteronism.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1.8 mL Frozen Plasma collected in a EDTA (lavender-top) tube
Minimum Volume
0.8 mL
Instructions
Specimen cannot be shared, draw a separate tube for any other plasma testing. Collect a mid-morning blood sample after patient has been upright (sitting, standing, or walking) for a minimum of 2 hours, then have them sit 5-15 minutes prior to collection. Centrifuge lavender top, transfer plasma to a plastic vial and freeze.
Patient Preparation
N/A
Storage
Plastic screw-cap vial
Transport Temperature
Frozen
Specimen Stability
- Room temperature: 24 hours
- Refrigerated: 24 hours
- Frozen: 28 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
Moderate to gross hemolysis; plasma collected in plasma separator tube; received thawed
Order Code
ARENIN
EPIC (Premier) Code
LAB3097
Includes
Aldosterone, LC/MS and Plasma Renin Activity, LC/MS/MS
CPT Code
- 82088
- 84244
Billing Code
- 670563
- 670564
CPT Statement
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153
14225 Newbrook Drive
Chantilly VA, 20153
Reference Range
Aldosterone
| Adult | |
| Upright 8:00-10:00 A.M. | ≤28 ng/dL |
| Upright 4:00-6:00 P.M. | ≤21 ng/dL |
| Supine 8:00-10:00 A.M. | 3-16 ng/dL |
| Pediatric | |
| 1-12 Months | 2-70 ng/dL |
| 1-4 Years | 2-37 ng/dL |
| 5-9 Years | ≤9 ng/dL |
| 10-13 Years | ≤21 ng/dL |
| 14-17 Years | ≤35 ng/dL |
| Infants | |
| Premature (31-35 Weeks) | ≤144 ng/dL |
| Term | ≤217 ng/dL |
| Tanner Stages | |
| II-III Males | 1-13 ng/dL |
| II-III Females | 2-20 ng/dL |
| IV-V Males | 3-14 ng/dL |
| IV-V Females | 4-32 ng/dL |
| Plasma Renin Activity | 0.25-5.82 ng/mL/h |
| Aldosterone/PRA Ratio | 0.9-28.9 Ratio |
Setup Schedule / Expected Turnaround Time
Monday - Saturday; Report available: 4 - 6 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1.8 mL Frozen Plasma collected in a EDTA (lavender-top) tube
Minimum Volume
0.8 mL
Instructions
Specimen cannot be shared, draw a separate tube for any other plasma testing. Collect a mid-morning blood sample after patient has been upright (sitting, standing, or walking) for a minimum of 2 hours, then have them sit 5-15 minutes prior to collection. Centrifuge lavender top, transfer plasma to a plastic vial and freeze.
Patient Preparation
N/A
Storage
Plastic screw-cap vial
Transport Temperature
Frozen
Specimen Stability
- Room temperature: 24 hours
- Refrigerated: 24 hours
- Frozen: 28 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
Moderate to gross hemolysis; plasma collected in plasma separator tube; received thawed
Result Information
Methodology
Chromatography/Mass Spectrometry
Testing Laboratory
N/A
Reference Range
Aldosterone
| Adult | |
| Upright 8:00-10:00 A.M. | ≤28 ng/dL |
| Upright 4:00-6:00 P.M. | ≤21 ng/dL |
| Supine 8:00-10:00 A.M. | 3-16 ng/dL |
| Pediatric | |
| 1-12 Months | 2-70 ng/dL |
| 1-4 Years | 2-37 ng/dL |
| 5-9 Years | ≤9 ng/dL |
| 10-13 Years | ≤21 ng/dL |
| 14-17 Years | ≤35 ng/dL |
| Infants | |
| Premature (31-35 Weeks) | ≤144 ng/dL |
| Term | ≤217 ng/dL |
| Tanner Stages | |
| II-III Males | 1-13 ng/dL |
| II-III Females | 2-20 ng/dL |
| IV-V Males | 3-14 ng/dL |
| IV-V Females | 4-32 ng/dL |
| Plasma Renin Activity | 0.25-5.82 ng/mL/h |
| Aldosterone/PRA Ratio | 0.9-28.9 Ratio |
Setup Schedule / Expected Turnaround Time
Monday - Saturday; Report available: 4 - 6 days