Apolipoprotein Evaluation
Test Summary
Apolipoprotein A1 is the primary protein associated with HDL cholesterol. Like HDL cholesterol, increased concentrations are associated with reduced risk of cardiovascular disease. Apolipoprotein B-100 is the primary protein associated with LDL cholesterol and other lipid particles. Like LDL cholesterol, increased concentrations are associated with increased risk of cardiovascular disease. The ratio of these two apolipoproteins correlates with risk of cardiovascular disease.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL serum collected in a serum separator tube (SST)
Minimum Volume
0.5 mL
Instructions
N/A
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 7 days
- Refrigerated: 10 days
- Frozen: 30 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
Grossly lipemic
Order Code
APO
EPIC (Premier) Code
LAB3634
Includes
Apolipoprotein A1
Apolipoprotein B
Apolipoprotein B/A1 Ratio
Apolipoprotein B
Apolipoprotein B/A1 Ratio
CPT Code
- 82172 (x2)
Billing Code
- 700000
CPT Statement
Methodology
Immunoassay (IA)
FDA Status
FDA Approved
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153
14225 Newbrook Drive
Chantilly VA, 20153
Reference Range
Apolipoprotein A1
Cardiovascular event risk category cut points (optimal, high) are based on the AMORIS study, Walldius G et al. J Intern Med. 2004;255:188-205.
Cardiovascular event risk category cut points (optimal, moderate, high) are based on National Lipid Association recommendations-Jacobson TA et al. J of Clin Lipid. 2015; 9: 129-169 and Jellinger PS et al. Endocr Pract. 2017;23(Suppl 2):1-87.
Apolipoprotein B/A1 Ratio
Cardiovascular event risk category cut points (optimal, moderate, high) are based on the AMORIS study, Walldius G et al. J Intern Med. 2004;255:188-205.
| Male | ≥115 mg/dL | |
| Female | ≥125 mg/dL | |
| Risk Category | Male | Female |
| Optimal | ≥115 mg/dL | ≥125 mg/dL |
| High | <115 mg/dL | <125 mg/dL |
| Apolipoprotein B | <90 mg/dL |
| Risk Category | |
| Optimal | <90 mg/dL |
| Moderate | 90-119 mg/dL |
| High | ≥120 mg/dL |
Apolipoprotein B/A1 Ratio
| Male | <0.77 | |
| Female | <0.63 | |
| Risk Category | Male | Female |
| Optimal | <0.77 | <0.63 |
| Moderate | 0.77-0.95 | 0.63-0.78 |
| High | >0.95 | >0.78 |
Setup Schedule / Expected Turnaround Time
Monday - Saturday; Report available: 1 - 2 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL serum collected in a serum separator tube (SST)
Minimum Volume
0.5 mL
Instructions
N/A
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 7 days
- Refrigerated: 10 days
- Frozen: 30 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
Grossly lipemic
Result Information
Methodology
Immunoassay (IA)
Testing Laboratory
N/A
Reference Range
Apolipoprotein A1
Cardiovascular event risk category cut points (optimal, high) are based on the AMORIS study, Walldius G et al. J Intern Med. 2004;255:188-205.
Cardiovascular event risk category cut points (optimal, moderate, high) are based on National Lipid Association recommendations-Jacobson TA et al. J of Clin Lipid. 2015; 9: 129-169 and Jellinger PS et al. Endocr Pract. 2017;23(Suppl 2):1-87.
Apolipoprotein B/A1 Ratio
Cardiovascular event risk category cut points (optimal, moderate, high) are based on the AMORIS study, Walldius G et al. J Intern Med. 2004;255:188-205.
| Male | ≥115 mg/dL | |
| Female | ≥125 mg/dL | |
| Risk Category | Male | Female |
| Optimal | ≥115 mg/dL | ≥125 mg/dL |
| High | <115 mg/dL | <125 mg/dL |
| Apolipoprotein B | <90 mg/dL |
| Risk Category | |
| Optimal | <90 mg/dL |
| Moderate | 90-119 mg/dL |
| High | ≥120 mg/dL |
Apolipoprotein B/A1 Ratio
| Male | <0.77 | |
| Female | <0.63 | |
| Risk Category | Male | Female |
| Optimal | <0.77 | <0.63 |
| Moderate | 0.77-0.95 | 0.63-0.78 |
| High | >0.95 | >0.78 |
Setup Schedule / Expected Turnaround Time
Monday - Saturday; Report available: 1 - 2 days