Amitriptyline
Test Summary
The tricyclics are used to treat depression. Nortriptyline is an active metabolite of Amitriptyline. Therapeutic drug levels are monitored to assist the physician assessing therapeutic response and to avoid toxicity.
Aliases
- Travil
- Amitriptyline &
- Metab: Elavil
- Endep
Specimen Collection
Special Instructions
N/A
Preferred Specimen
3 mL serum collected in a red-top tube (no gel)
Minimum Volume
1.5 mL
Instructions
N/A
Patient Preparation
Collect at steady-state trough concentration. Specimen should be collected >12 hours after dose.
Storage
N/A
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 5 days
- Refrigerated: 7 days
- Frozen: 30 days
Limitations
N/A
Other Acceptable Specimens
Plasma collected in an EDTA (lavender-top) tube, sodium heparin or lithium heparin (green-top) tube
Unacceptable Specimens
Gross hemolysis • Gel barrier/serum separator tube
Order Code
AMITRP
EPIC (Premier) Code
LAB033
Includes
Amitriptyline, Nortriptyline and Total
CPT Code
- 80335
Billing Code
- 700000
CPT Statement
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153
14225 Newbrook Drive
Chantilly VA, 20153
Reference Range
| Total | 100-250 mcg/L |
Setup Schedule / Expected Turnaround Time
Monday - Saturday; Report available: 1 day
Specimen Collection
Special Instructions
N/A
Preferred Specimen
3 mL serum collected in a red-top tube (no gel)
Minimum Volume
1.5 mL
Instructions
N/A
Patient Preparation
Collect at steady-state trough concentration. Specimen should be collected >12 hours after dose.
Storage
N/A
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 5 days
- Refrigerated: 7 days
- Frozen: 30 days
Limitations
N/A
Other Acceptable Specimens
Plasma collected in an EDTA (lavender-top) tube, sodium heparin or lithium heparin (green-top) tube
Unacceptable Specimens
Gross hemolysis • Gel barrier/serum separator tube
Result Information
Methodology
Chromatography/Mass Spectrometry
Testing Laboratory
N/A
Reference Range
| Total | 100-250 mcg/L |
Setup Schedule / Expected Turnaround Time
Monday - Saturday; Report available: 1 day