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Test Directory Aldosterone, LC/MS/MS

Aldosterone, LC/MS/MS

Test Summary

Approximately 1-2% of individuals with primary hypertension have primary hyperaldosteronism characterized by hypokalemia (low potassium) and low direct renin. Because serum aldosterone concentrations vary due to dietary sodium intake and body positions, some physicians prefer measurement of 24-hour urine concentrations for aldosterone.

Aliases

Specimen Collection

Special Instructions

N/A

Preferred Specimen

1 mL serum collected in a red-top tube (no gel)

Minimum Volume

0.25 mL

Instructions

Serum separator tubes are unacceptable. Draw blood in a no-additive (red-top) tube. Separate serum after clotting. Draw "upright" samples at least 1/2 hour after patient sits up.

Patient Preparation

N/A

Storage

N/A

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 4 days
Refrigerated: 7 days
Frozen: 28 days

Limitations

Aldosterone concentration varies based on body position and sodium intake. 24-hour urine specimens for aldosterone are an alternative.

Other Acceptable Specimens

Plasma collected in: EDTA (lavender-top) tube, sodium heparin or lithium heparin (green-top) tube

Unacceptable Specimens

Moderate to gross hemolysis • Serum separator tube (SST)

Order Code

ALDOSS

EPIC (Premier) Code

LAB1928

Includes

N/A

CPT Code

82088

Billing Code

700000

CPT Statement

Methodology

Chromatography/Mass Spectrometry

FDA Status

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Physician Attestation of Informed Consent

N/A

Testing Laboratory

Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153

Reference Range

Adult
Upright 8:00-10:00 am	≤28 ng/dL
Upright 4:00-6:00 pm	≤21 ng/dL
Supine 8:00-10:00 am	3-16 ng/dL
Pediatric
1-12 months**	2-70 ng/dL
1-4 years**	2-37 ng/dL
5-9 years	≤9 ng/dL
10-13 years	≤21 ng/dL
14-17 years	≤35 ng/dL
Infants
Premature (31-35 weeks)**	≤144 ng/dL
Term**	≤217 ng/dL
Tanner Stages**
II-III Males	1-13 ng/dL
II-III Females	2-20 ng/dL
IV-V Males	3-14 ng/dL
IV-V Females	4-32 ng/dL

**Pediatric data from J Clin Endocrinol Metab. 1992;75:1491 and J CLin Endocrinol Metab. 1989; 69;1133-1136.

Setup Schedule / Expected Turnaround Time

Monday - Saturday; Report available: 3 - 5 days