Aldosterone, LC/MS/MS
Order Code:
ALDOSS
Test Summary
Approximately 1-2% of individuals with primary hypertension have primary hyperaldosteronism characterized by hypokalemia (low potassium) and low direct renin. Because serum aldosterone concentrations vary due to dietary sodium intake and body positions, some physicians prefer measurement of 24-hour urine concentrations for aldosterone.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL serum collected in a red-top tube (no gel)
Minimum Volume
0.25 mL
Instructions
Serum separator tubes are unacceptable. Draw blood in a no-additive (red-top) tube. Separate serum after clotting. Draw "upright" samples at least 1/2 hour after patient sits up.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: 4 days
- Refrigerated: 7 days
- Frozen: 28 days
Limitations
Aldosterone concentration varies based on body position and sodium intake. 24-hour urine specimens for aldosterone are an alternative.
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube, sodium heparin or lithium heparin (green-top) tube
Unacceptable Specimens
Moderate to gross hemolysis • Serum separator tube (SST)
Order Code
ALDOSS
EPIC (Premier) Code
LAB1928
Includes
N/A
CPT Code
- 82088
Billing Code
- 670532
CPT Statement
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153
14225 Newbrook Drive
Chantilly VA, 20153
Department
Reference Testing
Reference Range
| Adult | |
| Upright 8:00-10:00 am | ≤28 ng/dL |
| Upright 4:00-6:00 pm | ≤21 ng/dL |
| Supine 8:00-10:00 am | 3-16 ng/dL |
| Pediatric | |
| 1-12 months** | 2-70 ng/dL |
| 1-4 years** | 2-37 ng/dL |
| 5-9 years | ≤9 ng/dL |
| 10-13 years | ≤21 ng/dL |
| 14-17 years | ≤35 ng/dL |
| Infants | |
| Premature (31-35 weeks)** | ≤144 ng/dL |
| Term** | ≤217 ng/dL |
| Tanner Stages** | |
| II-III Males | 1-13 ng/dL |
| II-III Females | 2-20 ng/dL |
| IV-V Males | 3-14 ng/dL |
| IV-V Females | 4-32 ng/dL |
**Pediatric data from J Clin Endocrinol Metab. 1992;75:1491 and J CLin Endocrinol Metab. 1989; 69;1133-1136.
Setup Schedule / Expected Turnaround Time
Monday - Saturday; Report available: 3 - 5 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL serum collected in a red-top tube (no gel)
Minimum Volume
0.25 mL
Instructions
Serum separator tubes are unacceptable. Draw blood in a no-additive (red-top) tube. Separate serum after clotting. Draw "upright" samples at least 1/2 hour after patient sits up.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: 4 days
- Refrigerated: 7 days
- Frozen: 28 days
Limitations
Aldosterone concentration varies based on body position and sodium intake. 24-hour urine specimens for aldosterone are an alternative.
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube, sodium heparin or lithium heparin (green-top) tube
Unacceptable Specimens
Moderate to gross hemolysis • Serum separator tube (SST)
Result Information
Methodology
Chromatography/Mass Spectrometry
Testing Laboratory
N/A
Reference Range
| Adult | |
| Upright 8:00-10:00 am | ≤28 ng/dL |
| Upright 4:00-6:00 pm | ≤21 ng/dL |
| Supine 8:00-10:00 am | 3-16 ng/dL |
| Pediatric | |
| 1-12 months** | 2-70 ng/dL |
| 1-4 years** | 2-37 ng/dL |
| 5-9 years | ≤9 ng/dL |
| 10-13 years | ≤21 ng/dL |
| 14-17 years | ≤35 ng/dL |
| Infants | |
| Premature (31-35 weeks)** | ≤144 ng/dL |
| Term** | ≤217 ng/dL |
| Tanner Stages** | |
| II-III Males | 1-13 ng/dL |
| II-III Females | 2-20 ng/dL |
| IV-V Males | 3-14 ng/dL |
| IV-V Females | 4-32 ng/dL |
**Pediatric data from J Clin Endocrinol Metab. 1992;75:1491 and J CLin Endocrinol Metab. 1989; 69;1133-1136.
Setup Schedule / Expected Turnaround Time
Monday - Saturday; Report available: 3 - 5 days