Adenosine Deaminase, Pleural Fluid
Test Summary
An elevated level of adenosine deaminase (AD) in human serum, plasma or select body fluids is used as a surrogate marker for inflammation or infectious disease. In CSF, pleural effusions, and pericardial fluid in particular, elevated AD activity has been shown to be associated with tubercular lesions. Additional disease states that may result in elevated AD activity include liver cirrhosis, liver fibrosis, certain malignancies (e. g. lymphoma), viral hepatitis, and autoimmune diseases (e. g. SLE, rheumatoid arthritis).
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
0.5 mL pleural fluid submitted in a sterile, plastic leak-proof container
Minimum Volume
0.1 mL
Instructions
N/A
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Frozen
Specimen Stability
- Room temperature: 24 hours
- Refrigerated: 72 hours
- Frozen: 6 months
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
N/A
Order Code
ADENOF
EPIC (Premier) Code
LAB3294
Includes
N/A
CPT Code
- 84311
Billing Code
- 700000
CPT Statement
Methodology
Kinetic Spectrophotometric (KS)
FDA Status
This test was performed using a kit that has not been cleared or approved by the FDA. The analytical performance characteristics of this test have been determined by Quest Diagnostics. This test should not be used for diagnosis without confirmation by other medically established means.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153
14225 Newbrook Drive
Chantilly VA, 20153
Reference Range
| Adenosine Deaminase, Pleural Fluid | <9.2 U/L |
| Tuberculosis | mean 92.1 U/L |
| Metastatic malignancies | mean 23.3 U/L |
| Mesotheliomas | mean 34.9 U/L |
| Pulmonary embolism | mean 23.8 U/L |
| Lymphoma | mean 64.3 U/L |
Setup Schedule / Expected Turnaround Time
Monday - Saturday morning; Report available: 1 day
Specimen Collection
Special Instructions
N/A
Preferred Specimen
0.5 mL pleural fluid submitted in a sterile, plastic leak-proof container
Minimum Volume
0.1 mL
Instructions
N/A
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Frozen
Specimen Stability
- Room temperature: 24 hours
- Refrigerated: 72 hours
- Frozen: 6 months
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
N/A
Result Information
Methodology
Kinetic Spectrophotometric (KS)
Testing Laboratory
N/A
Reference Range
| Adenosine Deaminase, Pleural Fluid | <9.2 U/L |
| Tuberculosis | mean 92.1 U/L |
| Metastatic malignancies | mean 23.3 U/L |
| Mesotheliomas | mean 34.9 U/L |
| Pulmonary embolism | mean 23.8 U/L |
| Lymphoma | mean 64.3 U/L |
Setup Schedule / Expected Turnaround Time
Monday - Saturday morning; Report available: 1 day