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17-Hydroxyprogesterone

Test Summary

17-Hydroxyprogesterone is elevated in patients with Congenital Adrenal Hyperplasia (CAH). CAH is a group of autosomal recessive diseases characterized by a deficiency of cortisol and an excess of ACTH concentration. 17-Hydroxyprogesterone is also useful in monitoring cortisol replacement therapy and in evaluating infertility and adrenal and ovarian neoplasms.

Aliases

  • N/A

Specimen Collection

Special Instructions

N/A

Preferred Specimen

0.5 mL serum collected in a red-top tube (no gel)

Minimum Volume

0.25 mL

Instructions

Separate serum after clotting. Ship serum refrigerated or frozen.

Patient Preparation

N/A

Storage

N/A

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

  • Room temperature: 48 hours
  • Refrigerated: 7 days
  • Frozen: 2 years

Limitations

N/A

Other Acceptable Specimens

Plasma collected in EDTA (lavender-top), or EDTA (royal blue-top), or sodium heparin (green-top), lithium heparin (green-top) tube

Unacceptable Specimens

Gross hemolysis • Serum separator tube

Order Code

17HYDP

EPIC (Premier) Code

LAB002

Includes

N/A

CPT Code

  • 83498

Billing Code

  • 670495

CPT Statement

CPT Statement

Methodology

Chromatography/Mass Spectrometry

FDA Status

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Physician Attestation of Informed Consent

N/A

Testing Laboratory

Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly VA, 20153

Department

Reference Testing

Reference Range

Adult Males
18-30 years 32-307 ng/dL
31-40 years 42-196 ng/dL
41-50 years 33-195 ng/dL
51-60 years 37-129 ng/dL

Adult Females
Pre-Menopausal Mid Follicular 23-102 ng/dL
Pre-Menopausal Surge 67-349 ng/dL
Pre-Menopausal Mid Luteal 139-431 ng/dL
Postmenopausal Phase ≤45 ng/dL
Pregnancy
First Trimester 78-457 ng/dL
Second Trimester 90-357 ng/dL
Third Trimester 144-578 ng/dL

Pediatric
Cord Blood** 1000-3000 ng/dL
Premature Infants** (31-35 weeks) ≤405 ng/dL
Term Infants (12 hrs)** <460 ng/dL
Values decline gradually to prepubertal levels 
   
Male and Female  
  <30 days Not established
  1-11 months ≤147 ng/dL
  1 year ≤139 ng/dL
  2 years ≤134 ng/dL
  3 years ≤131 ng/dL
  4 years ≤131 ng/dL
  5 years ≤133 ng/dL
  6 years ≤137 ng/dL
  7 years ≤145 ng/dL
  8 years ≤154 ng/dL
  9 years ≤166 ng/dL
  10 years ≤180 ng/dL
  11 years ≤196 ng/dL
  12 years ≤213 ng/dL
  13 years ≤233 ng/dL
  14 years ≤254 ng/dL
  15 years 19-276 ng/dL
  16 years 23-300 ng/dL
  17 years 26-325 ng/dL

Tanner Stages**
II-III Males 12-130 ng/dL
II-III Females 18-220 ng/dL
IV-V Males 51-190 ng/dL
IV-V Females 36-200 ng/dL

**Includes data from J Clin Endocrinol Metab.1991;73:674-686; J Clin Endocrinol Metab. 1989; 69:1133-1136; and J Clin Endocrinol Metab. 1994; 78:266-270. Pediatr Res 1988;23:525-529. MedLinePlus (accessed 6/16/14).

Setup Schedule / Expected Turnaround Time

Daily; Report available: 2 - 5 days

Specimen Collection

Special Instructions

N/A

Preferred Specimen

0.5 mL serum collected in a red-top tube (no gel)

Minimum Volume

0.25 mL

Instructions

Separate serum after clotting. Ship serum refrigerated or frozen.

Patient Preparation

N/A

Storage

N/A

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

  • Room temperature: 48 hours
  • Refrigerated: 7 days
  • Frozen: 2 years

Limitations

N/A

Other Acceptable Specimens

Plasma collected in EDTA (lavender-top), or EDTA (royal blue-top), or sodium heparin (green-top), lithium heparin (green-top) tube

Unacceptable Specimens

Gross hemolysis • Serum separator tube

Billing

CPT Code

  • 83498

Billing Code

  • 670495

CPT Statement

CPT Statement

Result Information

Methodology

Chromatography/Mass Spectrometry

Testing Laboratory

N/A

Reference Range

Adult Males
18-30 years 32-307 ng/dL
31-40 years 42-196 ng/dL
41-50 years 33-195 ng/dL
51-60 years 37-129 ng/dL

Adult Females
Pre-Menopausal Mid Follicular 23-102 ng/dL
Pre-Menopausal Surge 67-349 ng/dL
Pre-Menopausal Mid Luteal 139-431 ng/dL
Postmenopausal Phase ≤45 ng/dL
Pregnancy
First Trimester 78-457 ng/dL
Second Trimester 90-357 ng/dL
Third Trimester 144-578 ng/dL

Pediatric
Cord Blood** 1000-3000 ng/dL
Premature Infants** (31-35 weeks) ≤405 ng/dL
Term Infants (12 hrs)** <460 ng/dL
Values decline gradually to prepubertal levels 
   
Male and Female  
  <30 days Not established
  1-11 months ≤147 ng/dL
  1 year ≤139 ng/dL
  2 years ≤134 ng/dL
  3 years ≤131 ng/dL
  4 years ≤131 ng/dL
  5 years ≤133 ng/dL
  6 years ≤137 ng/dL
  7 years ≤145 ng/dL
  8 years ≤154 ng/dL
  9 years ≤166 ng/dL
  10 years ≤180 ng/dL
  11 years ≤196 ng/dL
  12 years ≤213 ng/dL
  13 years ≤233 ng/dL
  14 years ≤254 ng/dL
  15 years 19-276 ng/dL
  16 years 23-300 ng/dL
  17 years 26-325 ng/dL

Tanner Stages**
II-III Males 12-130 ng/dL
II-III Females 18-220 ng/dL
IV-V Males 51-190 ng/dL
IV-V Females 36-200 ng/dL

**Includes data from J Clin Endocrinol Metab.1991;73:674-686; J Clin Endocrinol Metab. 1989; 69:1133-1136; and J Clin Endocrinol Metab. 1994; 78:266-270. Pediatr Res 1988;23:525-529. MedLinePlus (accessed 6/16/14).

Setup Schedule / Expected Turnaround Time

Daily; Report available: 2 - 5 days