Neuromyelitis Optica (NMO)/Aquaporin-4-IgG Fluorescence-Activated Cell Sorting (FACS) Assay, Serum
Order Code: NMOFS
Test Summary
Diagnosis of a neuromyelitis optica spectrum disorder (NMOSD)
Diagnosis of autoimmune AQP4 channelopathy
Diagnosis of neuromyelitis optica (NMO)
Distinguishing NMOSD from multiple sclerosis early in the course of disease
Aliases
- Mayo code NMOFS
- NMO (Neruomyelitis Optica)
- NMO-IgG
- AQP4
- Aquaporin
- Devic's Antibody
- Transverse Myelitis Antibody
- Optic Neuritis Antibody
- Vision Loss Antibody
Specimen Collection
Special Instructions
N/A
Preferred Specimen
3 mL serum from a red top tube
Minimum Volume
2 mL
Instructions
N/A
Patient Preparation
N/A
Storage
Plastic screw-cap vial
Transport Temperature
Refrigerated
Specimen Stability
- Room Temperature: 72 hours
- Refrigerated: 28 days
- Frozen: 28 days
Limitations
AQP4-IgG antibodies may drop below detectable levels in setting of therapies for acute attack (IV methylprednisolone or plasmapheresis) or attack prevention (immunosuppressants).
Other Acceptable Specimens
Serum from a serum separator tube
Unacceptable Specimens
N/A
Order Code
NMOFS
EPIC (Premier) Code
LAB6451
Includes
N/A
CPT Code
- 86053
- if appropriate, 86053- NMO/AQP4-IgG FACS titer billed at an addiotional charge
Billing Code
- 650026
CPT Statement
Methodology
Flow Cytometry (FC)
FDA Status
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Mayo Clinic Laboratories
200 First Street SW
Rochester MN, 55905
200 First Street SW
Rochester MN, 55905
Department
Reference Testing
Reference Range
N/A
Setup Schedule / Expected Turnaround Time
Monday, Tuesday, Thursday; Report available: 5 - 8 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
3 mL serum from a red top tube
Minimum Volume
2 mL
Instructions
N/A
Patient Preparation
N/A
Storage
Plastic screw-cap vial
Transport Temperature
Refrigerated
Specimen Stability
- Room Temperature: 72 hours
- Refrigerated: 28 days
- Frozen: 28 days
Limitations
AQP4-IgG antibodies may drop below detectable levels in setting of therapies for acute attack (IV methylprednisolone or plasmapheresis) or attack prevention (immunosuppressants).
Other Acceptable Specimens
Serum from a serum separator tube
Unacceptable Specimens
N/A
Billing
CPT Code
- 86053
- if appropriate, 86053- NMO/AQP4-IgG FACS titer billed at an addiotional charge
Billing Code
- 650026
CPT Statement
Result Information
Methodology
Flow Cytometry (FC)
Testing Laboratory
N/A
Reference Range
N/A
Setup Schedule / Expected Turnaround Time
Monday, Tuesday, Thursday; Report available: 5 - 8 days