Neuromyelitis Optica (NMO)/Aquaporin-4-IgG Fluorescence-Activated Cell Sorting (FACS) Assay, Serum
Order Code:
NMOFS
Test Summary
Diagnosis of a neuromyelitis optica spectrum disorder (NMOSD)
Diagnosis of autoimmune AQP4 channelopathy
Diagnosis of neuromyelitis optica (NMO)
Distinguishing NMOSD from multiple sclerosis early in the course of disease
Aliases
- NMO (Neruomyelitis Optica) NMO-IgG AQP4 Aquaporin Devic'
- s Antibody Transverse Myelitis Antibody Optic Neuritis Antibody Vision Loss Antibody
Specimen Collection
Special Instructions
N/A
Preferred Specimen
3 mL serum from a red top tube
Minimum Volume
2 mL
Instructions
N/A
Patient Preparation
N/A
Storage
Pour off tube
Transport Temperature
Refrigerated
Specimen Stability
- Room Temperature: 72 hours
- Refrigerated: 28 days
- Frozen: 28 days
Limitations
AQP4-IgG antibodies may drop below detectable levels in setting of therapies for acute attack (IV methylprednisolone or plasmapheresis) or attack prevention (immunosuppressants).
Other Acceptable Specimens
Serum from a serum separator tube
Unacceptable Specimens
N/A
Order Code
NMOFS
EPIC (Premier) Code
LAB6451
Includes
N/A
CPT Code
- 86053
- if appropriate 86053- NMO/AQP4-IgG FACS titer billed at an additional charge
Billing Code
650026
CPT Statement
Methodology
Flow Cytometry (FC)
FDA Status
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Mayo Clinic Laboratories
200 First Street SW
Rochester MN, 55905
200 First Street SW
Rochester MN, 55905
Department
Reference Testing
Reference Range
N/A
Setup Schedule / Expected Turnaround Time
Monday, Tuesday, Thursday; Report available: 5 - 8 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
3 mL serum from a red top tube
Minimum Volume
2 mL
Instructions
N/A
Patient Preparation
N/A
Storage
Pour off tube
Transport Temperature
Refrigerated
Specimen Stability
- Room Temperature: 72 hours
- Refrigerated: 28 days
- Frozen: 28 days
Limitations
AQP4-IgG antibodies may drop below detectable levels in setting of therapies for acute attack (IV methylprednisolone or plasmapheresis) or attack prevention (immunosuppressants).
Other Acceptable Specimens
Serum from a serum separator tube
Unacceptable Specimens
N/A
Billing
CPT Code
- 86053
- if appropriate 86053- NMO/AQP4-IgG FACS titer billed at an additional charge
Billing Code
650026
CPT Statement
Result Information
Methodology
Flow Cytometry (FC)
Testing Laboratory
N/A
Reference Range
N/A
Setup Schedule / Expected Turnaround Time
Monday, Tuesday, Thursday; Report available: 5 - 8 days