MET (7Q31), FISH, Tissue
Test Summary
Providing prognostic information and guiding treatment primarily for patients with lung, gastric, and renal tumors as well as other tumor types
Aliases
- Mayo code METF
Specimen Collection
Special Instructions
N/A
Preferred Specimen
Submit only 1 of the following specimens:
Specimen Type: Tissue
Preferred: Tissue block Collection Instructions: Submit a formalin-fixed, paraffin-embedded (FFPE) tumor tissue block.
Blocks prepared with alternative fixation methods may be acceptable; provide fixation method used.
Specimen Type: Tissue
Preferred: Tissue block Collection Instructions: Submit a formalin-fixed, paraffin-embedded (FFPE) tumor tissue block.
Blocks prepared with alternative fixation methods may be acceptable; provide fixation method used.
Minimum Volume
Slides: 1 Hematoxylin and eosin stained and 2 unstained
Instructions
1. A pathology report is required in order for testing to be performed. Acceptable pathology reports include working drafts, preliminary pathology or surgical pathology reports.
2. A reason for testing must be provided. If this information is not provided, an appropriate indication for testing may be entered by Mayo Clinic Laboratories.
2. A reason for testing must be provided. If this information is not provided, an appropriate indication for testing may be entered by Mayo Clinic Laboratories.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Ambient
Specimen Stability
- N/A
Limitations
N/A
Other Acceptable Specimens
Acceptable: Slides Collection
Instructions: Four consecutive, unstained, 5 micron-thick sections placed on positively charged slides, and 1 hematoxylin and eosin-stained slide.
Instructions: Four consecutive, unstained, 5 micron-thick sections placed on positively charged slides, and 1 hematoxylin and eosin-stained slide.
Unacceptable Specimens
N/A
Order Code
M7Q31
EPIC (Premier) Code
LAB6446
Includes
N/A
CPT Code
- 88271x2
- 88291 – DNA probe
- each (first probe set)
- Interpretation and report 88271x2 – DNA probe
- each additional probe set (if appropriate) 88271x1 – DNA probe
- each coverage for sets containing 3 probes (if appropriate) 88271x2 – DNA probe
- each coverage for sets containing 4 probes (if appropriate) 88271x3 – DNA probe
- each coverage for sets containing 5 probes (if appropriate) 88274 w/modifier 52 – Interphase in situ hybridization
- < 25 cells
- each probe set (if appropriate) 88274 – Interphase in situ hybridization 25 to 99 cells
- each probe set (if appropriate) 88275 – Interphase in situ hybridization 100 to 300 cells
- each probe set (if appropriate)
Billing Code
- 671185
- 671186
CPT Statement
Methodology
Fluorescence In Situ Hybridization (FISH)
FDA Status
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Mayo Clinic Laboratories
200 First Street SW
Rochester MN, 55905
200 First Street SW
Rochester MN, 55905
Department
Reference Testing
Reference Range
N/A
Setup Schedule / Expected Turnaround Time
Monday - Friday; Report available: 7 - 10 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
Submit only 1 of the following specimens:
Specimen Type: Tissue
Preferred: Tissue block Collection Instructions: Submit a formalin-fixed, paraffin-embedded (FFPE) tumor tissue block.
Blocks prepared with alternative fixation methods may be acceptable; provide fixation method used.
Specimen Type: Tissue
Preferred: Tissue block Collection Instructions: Submit a formalin-fixed, paraffin-embedded (FFPE) tumor tissue block.
Blocks prepared with alternative fixation methods may be acceptable; provide fixation method used.
Minimum Volume
Slides: 1 Hematoxylin and eosin stained and 2 unstained
Instructions
1. A pathology report is required in order for testing to be performed. Acceptable pathology reports include working drafts, preliminary pathology or surgical pathology reports.
2. A reason for testing must be provided. If this information is not provided, an appropriate indication for testing may be entered by Mayo Clinic Laboratories.
2. A reason for testing must be provided. If this information is not provided, an appropriate indication for testing may be entered by Mayo Clinic Laboratories.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Ambient
Specimen Stability
- N/A
Limitations
N/A
Other Acceptable Specimens
Acceptable: Slides Collection
Instructions: Four consecutive, unstained, 5 micron-thick sections placed on positively charged slides, and 1 hematoxylin and eosin-stained slide.
Instructions: Four consecutive, unstained, 5 micron-thick sections placed on positively charged slides, and 1 hematoxylin and eosin-stained slide.
Unacceptable Specimens
N/A
Billing
CPT Code
- 88271x2
- 88291 – DNA probe
- each (first probe set)
- Interpretation and report 88271x2 – DNA probe
- each additional probe set (if appropriate) 88271x1 – DNA probe
- each coverage for sets containing 3 probes (if appropriate) 88271x2 – DNA probe
- each coverage for sets containing 4 probes (if appropriate) 88271x3 – DNA probe
- each coverage for sets containing 5 probes (if appropriate) 88274 w/modifier 52 – Interphase in situ hybridization
- < 25 cells
- each probe set (if appropriate) 88274 – Interphase in situ hybridization 25 to 99 cells
- each probe set (if appropriate) 88275 – Interphase in situ hybridization 100 to 300 cells
- each probe set (if appropriate)
Billing Code
- 671185
- 671186
CPT Statement
Result Information
Methodology
Fluorescence In Situ Hybridization (FISH)
Testing Laboratory
N/A
Reference Range
N/A
Setup Schedule / Expected Turnaround Time
Monday - Friday; Report available: 7 - 10 days