Banner Image

Test Directory

Encephalopathy Autoimmune Evaluation, CSF

Test Summary

Evaluating new onset encephalopathy (noninfectious or metabolic) comprising confusional states, psychosis, delirium, memory loss, hallucinations, movement disorders, sensory or motor complaints, seizures, dyssomnias, ataxias, nausea, vomiting, inappropriate antidiuresis, coma, dysautonomia's, or hypoventilation in spinal fluid specimens The following accompaniments should increase of suspicion for autoimmune encephalopathy: -Headache -Autoimmune stigmata (personal or family history or signs of diabetes mellitus, thyroid disorder, vitiligo, poliosis [premature graying], myasthenia gravis, rheumatoid arthritis, systemic lupus erythematosus) -History of cancer -Smoking history (20+ pack years) or other cancer risk factors -Inflammatory cerebrospinal fluid (or isolated protein elevation) -Neuroimaging signs suggesting inflammation Evaluating limbic encephalitis (noninfectious) Directing a focused search for cancer Investigating encephalopathy appearing in the course or wake of cancer therapy and not explainable by metastasis or drug effect.

Aliases

  • Limbic encephalitis

Specimen Collection

Special Instructions

N/A

Preferred Specimen

4 mL CSF in collection vial number 1

Minimum Volume

2 mL

Instructions

N/A

Patient Preparation

N/A

Storage

Sterile vial

Transport Temperature

Refrigerated

Specimen Stability

  • Room Temperature: 72 hours
  • Refrigerated: 28 days
  • Frozen: 28 days

Limitations

N/A

Other Acceptable Specimens

Any CSF collection vial

Unacceptable Specimens

Gross hemolysis, gross lipemia, gross icterus

Order Code

ENC2

EPIC (Premier) Code

LAB6441

Includes

N/A

CPT Code

  • 86255 x 23
  • 86341 x1
  • 84182 AGNBC (if appropriate)
  • 86255 AINCC (if appropriate)
  • 86256 AMPIC (if appropriate)
  • 84182 AMIBC (if appropriate)
  • 84182 AN1BC (if appropriate)
  • 84182 AN2BC (if appropriate)
  • 84182 CRMWC (if appropriate)
  • 86255 DPPCC (if appropriate)
  • 86256 DPPTC (if appropriate)
  • 86256 GABIC (if appropriate)
  • 86255 GFACC (if appropriate)
  • 86256 GFATC (if appropriate)
  • 86255 IG5CC (if appropriate)
  • 86256 IG5TC (if appropriate)
  • 86255 GL1CC (if appropriate)
  • 86256 GL1TC (if appropriate)
  • 86255 NFHCC (if appropriate)
  • 86256 NIFTC (if appropriate)
  • 86255 NFLCC (if appropriate)
  • 86256 NMDIC (if appropriate)
  • 84182 PC1BC (if appropriate)
  • 84182 PCTBC (if appropriate)

Billing Code

  • 650013
  • 650012

CPT Statement

Methodology

Indirect Immunofluorescence Assay (IFA),
Cell-Binding Assay (CBA),
Western Blot (WB),
Immunoblot (IB),
Radioimmunoassay (RIA)

FDA Status

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

Physician Attestation of Informed Consent

N/A

Testing Laboratory

Mayo Clinic Laboratories
200 First Street SW
Rochester MN, 55905

Department

Reference Testing

Reference Range

N/A

Setup Schedule / Expected Turnaround Time

Monday - Sunday; Report available: 8 -12 days

Specimen Collection

Special Instructions

N/A

Preferred Specimen

4 mL CSF in collection vial number 1

Minimum Volume

2 mL

Instructions

N/A

Patient Preparation

N/A

Storage

Sterile vial

Transport Temperature

Refrigerated

Specimen Stability

  • Room Temperature: 72 hours
  • Refrigerated: 28 days
  • Frozen: 28 days

Limitations

N/A

Other Acceptable Specimens

Any CSF collection vial

Unacceptable Specimens

Gross hemolysis, gross lipemia, gross icterus

Billing

CPT Code

  • 86255 x 23
  • 86341 x1
  • 84182 AGNBC (if appropriate)
  • 86255 AINCC (if appropriate)
  • 86256 AMPIC (if appropriate)
  • 84182 AMIBC (if appropriate)
  • 84182 AN1BC (if appropriate)
  • 84182 AN2BC (if appropriate)
  • 84182 CRMWC (if appropriate)
  • 86255 DPPCC (if appropriate)
  • 86256 DPPTC (if appropriate)
  • 86256 GABIC (if appropriate)
  • 86255 GFACC (if appropriate)
  • 86256 GFATC (if appropriate)
  • 86255 IG5CC (if appropriate)
  • 86256 IG5TC (if appropriate)
  • 86255 GL1CC (if appropriate)
  • 86256 GL1TC (if appropriate)
  • 86255 NFHCC (if appropriate)
  • 86256 NIFTC (if appropriate)
  • 86255 NFLCC (if appropriate)
  • 86256 NMDIC (if appropriate)
  • 84182 PC1BC (if appropriate)
  • 84182 PCTBC (if appropriate)

Billing Code

  • 650013
  • 650012

CPT Statement

Result Information

Methodology

Indirect Immunofluorescence Assay (IFA),
Cell-Binding Assay (CBA),
Western Blot (WB),
Immunoblot (IB),
Radioimmunoassay (RIA)

Testing Laboratory

N/A

Reference Range

N/A

Setup Schedule / Expected Turnaround Time

Monday - Sunday; Report available: 8 -12 days