Dementia Autoimmune Evaluation, Serum
Order Code:
DMS2
Test Summary
Investigating new onset dementia and cognitive impairment plus 1 or more of the following accompaniments using cerebrospinal fluid specimens: -Rapid onset and progression -Fluctuating course -Psychiatric accompaniments (psychosis, hallucinations) -Movement disorder (myoclonus, tremor, dyskinesias) -Headache -Autoimmune stigmata (personal history or family history or signs of diabetes mellitus, thyroid disorder, vitiligo, poliosis [premature graying], myasthenia gravis, rheumatoid arthritis, systemic lupus erythematosus) -Smoking history (20+ pack years) or other cancer risk factors -History of cancer -Inflammatory cerebrospinal fluid -Neuroimaging findings atypical for degenerative etiology.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
4 mL serum from a red top tube
Minimum Volume
2.5 mL
Instructions
N/A
Patient Preparation
For optimal antibody detection, specimen collection is recommended before initiation of immunosuppressant medication or intravenous immunoglobulin treatment. For 24 hours before specimen collection, patient should not receive general anesthetic or take muscle-relaxant drugs.
Storage
Plastic screw-cap vial
Transport Temperature
Refrigerated
Specimen Stability
- Room Temperature: 72 hours
- Refrigerated: 28 days
- Frozen: 28 days
Limitations
N/A
Other Acceptable Specimens
Serum from a serum separator tube
Unacceptable Specimens
Gross hemolysis, gross lipemia, gross icterus
Order Code
DMS2
EPIC (Premier) Code
LAB6503
Includes
N/A
CPT Code
- 86255 x 21
- 86341
- 83519-ARBI (if appropriate)
- 84182-AGNBS (if appropriate)
- 86255-AINCS (if appropriate)
- 86256-AMPIS (if appropriate)
- 84182-AMIBS (if appropriate)
- 84182-AN1BS (if appropriate)
- 84182-AN2BS (if appropriate)
- 84182-CRMWS (if appropriate)
- 86255-DPPCS (if appropriate)
- 86256-DPPTS (if appropriate)
- 86256-GABIS (if appropriate)
- 86255-GFACS (if appropriate)
- 86256-GFATS (if appropriate)
- 86255-IG5CS (if appropriate)
- 86256-IG5TS (if appropriate)
- 86255-GL1CS (if appropriate)
- 86256-GL1TS (if appropriate)
- 86255-NFHCS (if appropriate)
- 86256-NIFTS (if appropriate)
- 86255-NFLCS (if appropriate)
- 86256-NMDIS (if appropriate)
- 84182-PC1BS (if appropriate)
- 86255-PCABP (if appropriate)
- 84182-PCTBS (if appropriate)
Billing Code
- 650010
- 650009
CPT Statement
Methodology
Indirect Immunofluorescence Assay (IFA),
Cell-Binding Assay (CBA),
Western Blot (WB),
Immunoblot (IB),
Radioimmunoassay (RIA)
Cell-Binding Assay (CBA),
Western Blot (WB),
Immunoblot (IB),
Radioimmunoassay (RIA)
FDA Status
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Mayo Clinic Laboratories
200 First Street SW
Rochester MN, 55905
200 First Street SW
Rochester MN, 55905
Department
Reference Testing
Reference Range
N/A
Setup Schedule / Expected Turnaround Time
Monday - Sunday; Report available: 8 -12 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
4 mL serum from a red top tube
Minimum Volume
2.5 mL
Instructions
N/A
Patient Preparation
For optimal antibody detection, specimen collection is recommended before initiation of immunosuppressant medication or intravenous immunoglobulin treatment. For 24 hours before specimen collection, patient should not receive general anesthetic or take muscle-relaxant drugs.
Storage
Plastic screw-cap vial
Transport Temperature
Refrigerated
Specimen Stability
- Room Temperature: 72 hours
- Refrigerated: 28 days
- Frozen: 28 days
Limitations
N/A
Other Acceptable Specimens
Serum from a serum separator tube
Unacceptable Specimens
Gross hemolysis, gross lipemia, gross icterus
Billing
CPT Code
- 86255 x 21
- 86341
- 83519-ARBI (if appropriate)
- 84182-AGNBS (if appropriate)
- 86255-AINCS (if appropriate)
- 86256-AMPIS (if appropriate)
- 84182-AMIBS (if appropriate)
- 84182-AN1BS (if appropriate)
- 84182-AN2BS (if appropriate)
- 84182-CRMWS (if appropriate)
- 86255-DPPCS (if appropriate)
- 86256-DPPTS (if appropriate)
- 86256-GABIS (if appropriate)
- 86255-GFACS (if appropriate)
- 86256-GFATS (if appropriate)
- 86255-IG5CS (if appropriate)
- 86256-IG5TS (if appropriate)
- 86255-GL1CS (if appropriate)
- 86256-GL1TS (if appropriate)
- 86255-NFHCS (if appropriate)
- 86256-NIFTS (if appropriate)
- 86255-NFLCS (if appropriate)
- 86256-NMDIS (if appropriate)
- 84182-PC1BS (if appropriate)
- 86255-PCABP (if appropriate)
- 84182-PCTBS (if appropriate)
Billing Code
- 650010
- 650009
CPT Statement
Result Information
Methodology
Indirect Immunofluorescence Assay (IFA),
Cell-Binding Assay (CBA),
Western Blot (WB),
Immunoblot (IB),
Radioimmunoassay (RIA)
Cell-Binding Assay (CBA),
Western Blot (WB),
Immunoblot (IB),
Radioimmunoassay (RIA)
Testing Laboratory
N/A
Reference Range
N/A
Setup Schedule / Expected Turnaround Time
Monday - Sunday; Report available: 8 -12 days