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Test Directory Prostaglandin D2 (PG D2), Urine

Prostaglandin D2 (PG D2), Urine

Test Summary

Prostaglandins are fatty acids derived from arachidonic acid metabolism. They are closely related to the Thromboxane's and Leukotrienes. Prostaglandin D2 is derived mainly from Prostaglandin H2, and is metabolized to Dihydroketo Prostaglandin D2. Prostaglandin D2 is excreted directly into the urine. The sites of highest Prostaglandin D2 activity are the brain, spinal cord, intestines, and stomach. Prostaglandin D2 is the major Prostaglandin produced by uterine tissue. Prostaglandin D2 is a potent bronchoconstrictor, neuromodulator, and anti-antithrombin agent. It also stimulates the secretion of Pancreatic Glucagon. Prostaglandin D2 has been found to have an anti- metastatic effect on many malignant tumor cells. Prostaglandin D2 production and circulating levels are drastically suppressed by aspirin and indomethacin.

Aliases

Mayo code FPD2U, PG D2, D2 URINE

Specimen Collection

Special Instructions

N/A

Preferred Specimen

10 mL random urine, freeze immediately

Minimum Volume

5 mL

Instructions

Specimen must be frozen within 30 minutes of collection.

Patient Preparation

Patient should not be on aspirin, indomethacin, or anti-inflammatory medications, if possible, for at least 48 hours prior to collection of specimen.

Storage

Plastic screw-cap vial

Transport Temperature

Frozen

Specimen Stability

Room Temperature: NA
Refrigerated: NA
Frozen: 180 DAYS

Limitations

N/A

Other Acceptable Specimens

N/A

Unacceptable Specimens

24 hour urine, preserved urine

Order Code

PGD2

EPIC (Premier) Code

LAB6460

Includes

N/A

CPT Code

84150

Billing Code

670417

CPT Statement

Methodology

Direct EIA/ELISA

FDA Status

This test was performed using a kit that has not been cleared or approved by the FDA and is designated as research use only. The analytic performance characteristics of this test have been determined by Inter Science Institute. This test is not intended for diagnosis or patient management decisions without confirmation by other medically established means.

Physician Attestation of Informed Consent

N/A

Testing Laboratory

Inter Science Institute
944 West Hyde Park
Inglewood CA, 90302

Department

Reference Testing

Reference Range

N/A

Setup Schedule / Expected Turnaround Time

Daily; Report available: 10 - 14 days