2,3-Dinor 11 Beta-Prostaglandin F2 Alpha, 24 Hour Urine
Order Code: 23BPT
Test Summary
Screening for mast cell activation disorders including systemic mastocytosis using 24 hour urine specimens
Aliases
- 11 Beta-Prostaglandin F2 Alpha; 23BPG
Specimen Collection
Special Instructions
N/A
Preferred Specimen
5 mL unpreserved 24 hour urine
Minimum Volume
4 mL
Instructions
Collect urine and refrigerate for 24 hours
Patient Preparation
Patients taking aspirin or nonsteroidal anti-inflammatory drugs (NSAID) may have decreased concentrations of prostaglandin F2 alpha. If medically feasible, for 2 weeks before collection, patient should not take aspirin and for 72 hours prior to collection, patient should not take NSAIDs.
Storage
Plastic screw-cap vial or plastic urine cup
Transport Temperature
Refrigerated
Specimen Stability
- Room Temperature: 8 hours
- Refrigerated: 14 days
- Frozen: 30 days
Limitations
Elevated levels of 2,3-dinor-11beta-prostaglandin F2 alpha (2,3 BPG) in urine are not specific for systemic mast cell disease and may be found in patients with angioedema, diffuse urticaria, or myeloproliferative diseases in the absence of diffuse mast cell proliferation. Systemic mast cell disease is a heterogeneous disease, and some patients may not have elevated 2,3 BPG in urine. Patients taking aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) may have decreased concentrations of prostaglandin F2 alpha if dosage has not been discontinued for 2 weeks or 72 hours, respectively.
Other Acceptable Specimens
N/A
Unacceptable Specimens
N/A
Order Code
23BPT
EPIC (Premier) Code
LAB6752
Includes
2,3-dinor 11B-Prostaglandin F2a; Creatinine, 24 HR
CPT Code
- 84150
Billing Code
- 650047
CPT Statement
Methodology
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS, Enzymatic Colorimetric Assay)
FDA Status
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Creatinine performed at:
Mayo Clinic Laboratories
200 First Street SW
Rochester MN, 55905
2,3-dinor 11B-Prostaglandin F2a performed at:
Mayo Clinic Laboratories -- Rochester Superior Drive
3050 Superior Drive NW
Rochester MN, 55901
Mayo Clinic Laboratories
200 First Street SW
Rochester MN, 55905
2,3-dinor 11B-Prostaglandin F2a performed at:
Mayo Clinic Laboratories -- Rochester Superior Drive
3050 Superior Drive NW
Rochester MN, 55901
Department
Reference Testing
Reference Range
N/A
Setup Schedule / Expected Turnaround Time
Tuesday, Thursday; Reports available: 3 - 8 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
5 mL unpreserved 24 hour urine
Minimum Volume
4 mL
Instructions
Collect urine and refrigerate for 24 hours
Patient Preparation
Patients taking aspirin or nonsteroidal anti-inflammatory drugs (NSAID) may have decreased concentrations of prostaglandin F2 alpha. If medically feasible, for 2 weeks before collection, patient should not take aspirin and for 72 hours prior to collection, patient should not take NSAIDs.
Storage
Plastic screw-cap vial or plastic urine cup
Transport Temperature
Refrigerated
Specimen Stability
- Room Temperature: 8 hours
- Refrigerated: 14 days
- Frozen: 30 days
Limitations
Elevated levels of 2,3-dinor-11beta-prostaglandin F2 alpha (2,3 BPG) in urine are not specific for systemic mast cell disease and may be found in patients with angioedema, diffuse urticaria, or myeloproliferative diseases in the absence of diffuse mast cell proliferation. Systemic mast cell disease is a heterogeneous disease, and some patients may not have elevated 2,3 BPG in urine. Patients taking aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) may have decreased concentrations of prostaglandin F2 alpha if dosage has not been discontinued for 2 weeks or 72 hours, respectively.
Other Acceptable Specimens
N/A
Unacceptable Specimens
N/A
Result Information
Methodology
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS, Enzymatic Colorimetric Assay)
Testing Laboratory
N/A
Reference Range
N/A
Setup Schedule / Expected Turnaround Time
Tuesday, Thursday; Reports available: 3 - 8 days