Sjogren's Antibodies
Test Summary
Sjögren's antibodies (SS-B) is detected in approximately 15% of patients with Sjögren's Syndrome. Sjögren's antibody (SS-B) is present only if Sjögren's antibody (SS-A) is also detected. The presence of both antibodies (SS-A and SS-B) strengthen the diagnosis of Sjögren's Syndrome and conveys prognostic information.
Aliases
- Anti-RO Anti-LA
- Sjogrens
- Sjogrens Antibodies
- Sjogrens Antibody
- SSA Antibody
- SSA / SSB
- SSB Antibody
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL serum (minimum 0.5 mL)
Minimum Volume
0.5 mL
Instructions
SST or Red top: Avoid hemolysis. Invert a minimum of 5 times, then allow to clot in an upright position for 30 minutes. Centrifuge the tube for at least 10 minutes. Keep tightly stoppered.
Patient Preparation
N/A
Storage
SST (speckled top), Red top , Plastic Vial (transfer) tube
Transport Temperature
Refrigerated (preferred)
Specimen Stability
- Room Temperature = n/a
- Refrigerated = 5 days
- Frozen = at least 7 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
N/A
Order Code
SSASSB
EPIC (Premier) Code
LAB716
Includes
Includes SS-A and SS-B
CPT Code
- 86235(2)
Billing Code
- 500340
CPT Statement
Methodology
Enzyme Immunoassay (EIA)
FDA Status
FDA Approved
Physician Attestation of Informed Consent
N/A
Testing Laboratory
CompuNet Clinical Laboratories, LLC
2308 Sandridge Drive
Moraine OH, 45439
2308 Sandridge Drive
Moraine OH, 45439
Department
Molecular/Serology
Reference Range
| SEX | AGE | Report Normals | |
| Sjogrens Antibodies (SSA) | N/M/F | 1000Y | < 20 = Negative |
| > = 20 = Positive | |||
| Values between 20 and 40 are weak positives and repeat testing is recommended in 3 - 6 months | |||
| Sjogrens Antibodies (SSB) | N/M/F | 1000Y | <20 = Negative |
| > = 20 = Positive | |||
| Values between 20 and 40 are weak positives and repeat testing is recommended in 3 - 6 months | |||
| Antibodies to SSA (RO) and SSB (LA) are observed with the highest frequency in Sjogren"s Syndrome, although these antibodies are also found in a significant percentage of patients with SLE. | |||
Setup Schedule / Expected Turnaround Time
Monday, Wednesday, Friday; BS; Reports available: 3 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL serum (minimum 0.5 mL)
Minimum Volume
0.5 mL
Instructions
SST or Red top: Avoid hemolysis. Invert a minimum of 5 times, then allow to clot in an upright position for 30 minutes. Centrifuge the tube for at least 10 minutes. Keep tightly stoppered.
Patient Preparation
N/A
Storage
SST (speckled top), Red top , Plastic Vial (transfer) tube
Transport Temperature
Refrigerated (preferred)
Specimen Stability
- Room Temperature = n/a
- Refrigerated = 5 days
- Frozen = at least 7 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
N/A
Result Information
Methodology
Enzyme Immunoassay (EIA)
Testing Laboratory
N/A
Reference Range
| SEX | AGE | Report Normals | |
| Sjogrens Antibodies (SSA) | N/M/F | 1000Y | < 20 = Negative |
| > = 20 = Positive | |||
| Values between 20 and 40 are weak positives and repeat testing is recommended in 3 - 6 months | |||
| Sjogrens Antibodies (SSB) | N/M/F | 1000Y | <20 = Negative |
| > = 20 = Positive | |||
| Values between 20 and 40 are weak positives and repeat testing is recommended in 3 - 6 months | |||
| Antibodies to SSA (RO) and SSB (LA) are observed with the highest frequency in Sjogren"s Syndrome, although these antibodies are also found in a significant percentage of patients with SLE. | |||
Setup Schedule / Expected Turnaround Time
Monday, Wednesday, Friday; BS; Reports available: 3 days