Test Summary

Autoantibodies to Myeloperoxidase (MPO) are commonly associated with Microscopic Polyangiitis, Churg-Strauss Syndrome, and Idiopathic, Paucimmune, Crescentic and Necrotizing Glomerulonephritis. These autoantibodies are clinically helpful in determining active versus inactive disease states. In monitoring the effect of therapy, and in evaluating the possibility of relapse in Microscopic Polyangiitis and its renal-limited variant.
Autoantibodies to Proteinase-3 (PR-3) may be seen in most patients with Wegener"s Granulomatosis. But also in 30% of patients with Microscopic Polyangiitis and Churge Strauss Syndrome. These autoantibodies are clinically helpful in determining active versus inactive disease states. In monitoring the effect of therapy and in evaluating the possibility of relapse.

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