Histone Antibodies
Test Summary
Histone antibodies have been detected in 18-53% of patients with SLE. Up to 95% of patients with drug-induced lupus have histone antibodies and they are the predominant antibodies in these patients. Other types of SLE usually have a variety of antibodies.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL serum (minimum 0.3 mL)
Minimum Volume
0.3 mL
Instructions
Avoid hemolysis. Invert a minimum of 5 times then allow to clot in an upright position for 30 minutes. Centrifuge the SST for at least 10 minutes. Keep tightly stoppered.
Patient Preparation
N/A
Storage
SST (speckled top) tube
Transport Temperature
Refrigerated (preferred)
Specimen Stability
- Room Temperature = n/a
- Refrigerated = 5 days
- Frozen = at least 7 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
N/A
Order Code
HISTON
EPIC (Premier) Code
LAB248
Includes
N/A
CPT Code
- 83516
Billing Code
- 300279
CPT Statement
Methodology
Enzyme Immunoassay (EIA)
FDA Status
FDA Approved
Physician Attestation of Informed Consent
N/A
Testing Laboratory
CompuNet Clinical Laboratories, LLC
2308 Sandridge Drive
Moraine OH, 45439
2308 Sandridge Drive
Moraine OH, 45439
Department
Molecular/Serology
Reference Range
| SEX | AGE | Report Normals | Units |
| N/M/F | 1000Y | < 1.0 = Negative | |
| 1.0 - 1.5 = Weak Positive | |||
| > 1.5 = Positive |
Setup Schedule / Expected Turnaround Time
Monday, Wednesday, Friday; BS; Reports available: 1 - 3 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL serum (minimum 0.3 mL)
Minimum Volume
0.3 mL
Instructions
Avoid hemolysis. Invert a minimum of 5 times then allow to clot in an upright position for 30 minutes. Centrifuge the SST for at least 10 minutes. Keep tightly stoppered.
Patient Preparation
N/A
Storage
SST (speckled top) tube
Transport Temperature
Refrigerated (preferred)
Specimen Stability
- Room Temperature = n/a
- Refrigerated = 5 days
- Frozen = at least 7 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
N/A
Result Information
Methodology
Enzyme Immunoassay (EIA)
Testing Laboratory
N/A
Reference Range
| SEX | AGE | Report Normals | Units |
| N/M/F | 1000Y | < 1.0 = Negative | |
| 1.0 - 1.5 = Weak Positive | |||
| > 1.5 = Positive |
Setup Schedule / Expected Turnaround Time
Monday, Wednesday, Friday; BS; Reports available: 1 - 3 days