Cryoglobulin
CRYOB
Test Summary
Cryoglobulins are proteins that precipitate from serum at temperatures below 37C degrees. Most precipitate when serum is cooled at 4C degrees, but some gel even at room temperature. Many of the cryoglobulins have the ability to fix complement and initiate an inflammatory reaction similar to classic antigen-antibody complexes and thus, probably play a significant role in the pathogenesis of viral disease with the production of lesions of vasculitis and glomerulonephritis. Cryoglobulin have been detected in a wide variety of lymphoproliferative, autoimmune and infectious diseases.
Aliases
N/A
Specimen Collection
Special Instructions
Allow blood to clot for one (1) hour in a 37°C water bath, incubator, heat block, or heel warmer. After clotting, centrifuge the specimen as quickly as possible. It is not necessary to use a warm centrifuge but do not use a refrigerated one. Decant all of the serum into one transport vial (do not aliquot any of the cryoglobulin serum into any other tube). Transport at room temperature preferred.
Preferred Specimen
Collect 2 FULL red-top (no gel) tubes to yield 3 mL serum at laboratory
Minimum Volume
Collect 2 FULL red-top (no gel) tubes to yield 2 mL serum at laboratory
Instructions
MUST BE COLLECTED AT SANDRIDGE, HOSPITAL, OR PSC/CLIENT WITH INCUBATION REQUIREMENTS. ONLY COLLECT MONDAY- THURSDAY.
Patient Preparation
Overnight fasting is required
Storage
Plastic screw top vial
Transport Temperature
Room temperature
Specimen Stability
- Room temperature =72 hours
- Refrigerated = unacceptable
- Frozen = unacceptable
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
Lipemic, Icteric, Serum sperarator tube (SST)
Order Code
CRYOB
EPIC (Premier) Code
LAB131
Includes
If cryoglobulin is present, they are semi-quantitated (as % cryoglobulin) by cryocrit.
CPT Code
82595
Billing Code
300098
CPT Statement
Methodology
Cryocrit method
FDA Status
FDA Approved
Physician Attestation of Informed Consent
N/A
Testing Laboratory
2308 Sandridge Drive
Moraine OH, 45439
Department
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Sunday - Friday; Report available: 6 - 8 days
Specimen Collection
Special Instructions
Allow blood to clot for one (1) hour in a 37°C water bath, incubator, heat block, or heel warmer. After clotting, centrifuge the specimen as quickly as possible. It is not necessary to use a warm centrifuge but do not use a refrigerated one. Decant all of the serum into one transport vial (do not aliquot any of the cryoglobulin serum into any other tube). Transport at room temperature preferred.
Preferred Specimen
Collect 2 FULL red-top (no gel) tubes to yield 3 mL serum at laboratory
Minimum Volume
Collect 2 FULL red-top (no gel) tubes to yield 2 mL serum at laboratory
Instructions
MUST BE COLLECTED AT SANDRIDGE, HOSPITAL, OR PSC/CLIENT WITH INCUBATION REQUIREMENTS. ONLY COLLECT MONDAY- THURSDAY.
Patient Preparation
Overnight fasting is required
Storage
Plastic screw top vial
Transport Temperature
Room temperature
Specimen Stability
- Room temperature =72 hours
- Refrigerated = unacceptable
- Frozen = unacceptable
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
Lipemic, Icteric, Serum sperarator tube (SST)
Result Information
Methodology
Cryocrit method
Testing Laboratory
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Sunday - Friday; Report available: 6 - 8 days