FISH, Myeloma Panel with Reflex
Order Code:
FSHMFX
Test Summary
Plasma cell myeloma is characterized by the proliferation of malignant monoclonal plasma cells in the bone marrow. This FISH panel is designed for clinical risk classification. Initial FISH testing is performed to detect deletion of TP53 (17p), rearrangements of IGH (14q32), rearrangements of MYC, gain of 1q, deletion of 1p, deletion 13q/monosomy 13, and gain (trisomy) of chromosome 9, 11, and 15 (for hyperdiploidy). When IGH rearrangement is positive, FISH for the specific IGH rearrangements t(11;14), t(4;14), t(14;16), t(14;20) will be performed.
Aliases
- MM
- Fluorescence in situ Hybridization
- Multiple myeloma
- Dyscrasia
- Plasmacytoma
- Plasma Cell Myeloma
- PCM
- MGUS
- Plasma Cell Neoplasm
Specimen Collection
Special Instructions
N/A
Preferred Specimen
3 mL bone marrow collected in a sodium heparin (green-top) tube
Minimum Volume
1 mL
Instructions
N/A
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room temperature
Specimen Stability
- Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Limitations
N/A
Other Acceptable Specimens
Bone marrow collected in: EDTA (lavender-top) tube
Unacceptable Specimens
N/A
Order Code
FSHMFX
EPIC (Premier) Code
LAB6928
Includes
If the result for IGH rearrangement is positive during initial FISH analysis, then FISH, Myeloma, IGH Panel will be performed at an additional charge (CPT codes(s): 88271 (x8), 88275 (x4)).
CPT Code
- 88271 (x13)
- 88275 (x6)
- If the result for IGH rearrangement is positive during initial FISH analysis
- then FISH
- Myeloma
- IGH Panel will be performed at an additional charge (CPT codes(s): 88271 (x8)
- 88275 (x4)).
Billing Code
N/A
CPT Statement
Methodology
Fluorescence In Situ Hybridization (FISH)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Testing
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Daily; Report available: 7 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
3 mL bone marrow collected in a sodium heparin (green-top) tube
Minimum Volume
1 mL
Instructions
N/A
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room temperature
Specimen Stability
- Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Limitations
N/A
Other Acceptable Specimens
Bone marrow collected in: EDTA (lavender-top) tube
Unacceptable Specimens
N/A
Billing
CPT Code
- 88271 (x13)
- 88275 (x6)
- If the result for IGH rearrangement is positive during initial FISH analysis
- then FISH
- Myeloma
- IGH Panel will be performed at an additional charge (CPT codes(s): 88271 (x8)
- 88275 (x4)).
Billing Code
N/A
CPT Statement
Result Information
Methodology
Fluorescence In Situ Hybridization (FISH)
Testing Laboratory
N/A
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Daily; Report available: 7 days