FISH, Myeloma Panel with Reflex
FSHMFX
Test Summary
Plasma cell myeloma is characterized by the proliferation of malignant monoclonal plasma cells in the bone marrow. This FISH panel designed for clinical risk classification. Initial FISH testing is performed to detect deletion of TP53 (17p), rearrangements of IGH (14q32), rearrangements of MYC, gain of 1 q, deletion of 1p, deletion of 13q/monosomy13, and gain (trisomy) of chromosome 9,11, and 15 (for hyperdiploidy). When IGH rearrangement is positive, FISH for the specific IGH rearrangements t(11;14), t(4;14), t(14;16), t(14;20) will be performed.
Aliases
MM
Fluorescence is situ Hybridization
Multiple Myeloma
Dyscrasia
Plasmacytoma
Plasma Cell Myeloma
PCM
MGUS
Plasma Cell Neoplasma
Specimen Collection
Special Instructions
N/A
Preferred Specimen
3 mL Bone Marrow collected in a sodium heparin (green-top) tube
Minimum Volume
1 mL
Instructions
N/A
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room Temperature
Specimen Stability
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. DO NOT FREEZE. DO NOT REJECT.
Limitations
If the result for IGH rearrangement is positive during initial FISH analysis, then FISH, Myeloma, IGH Panel will be performed at an additional charge (CPT codes 88271 (x8), 88275 (x4)
Other Acceptable Specimens
N/A
Unacceptable Specimens
N/A
Order Code
FSHMFX
EPIC (Premier) Code
LAB6928
Includes
N/A
CPT Code
88271 (x13), 88275 (x6), If the result for IGH rearrangement is positive during initial FISH analysis, then FISH, Myeloma, IGH Panel will be performed at an additional charge (CPT codes: 88271 (x8), 88275 (x4)
Billing Code
CPT Statement
Methodology
Fluorescence in situ Hybridization (FISH)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay had been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Specimen Collection
Special Instructions
N/A
Preferred Specimen
3 mL Bone Marrow collected in a sodium heparin (green-top) tube
Minimum Volume
1 mL
Instructions
N/A
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room Temperature
Specimen Stability
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. DO NOT FREEZE. DO NOT REJECT.
Limitations
If the result for IGH rearrangement is positive during initial FISH analysis, then FISH, Myeloma, IGH Panel will be performed at an additional charge (CPT codes 88271 (x8), 88275 (x4)
Other Acceptable Specimens
N/A
Unacceptable Specimens
N/A
Billing
CPT Code
88271 (x13), 88275 (x6), If the result for IGH rearrangement is positive during initial FISH analysis, then FISH, Myeloma, IGH Panel will be performed at an additional charge (CPT codes: 88271 (x8), 88275 (x4)
Billing Code
CPT Statement
Result Information
Methodology
Fluorescence in situ Hybridization (FISH)
Testing Laboratory
Reference Range
See Laboratory Report