Voriconazole, Serum
Order Code:
VORIS
Test Summary
Monitoring trough levels of voriconazole is suggested for:
- Individuals with reduced liver function
- Individuals with cytochrome P450 (CYP) 2C19 alterations associated with poor metabolic function
- Patients taking other medications that affect CYP2C19 activity
- Patients experiencing potential toxicity
Aliases
Vfend (Voriconazole)
Specimen Collection
Special Instructions
Trough level (ie, immediately before next dose) monitoring is recommended.
Preferred Specimen
2 mL serum from a red top tube
Minimum Volume
0.6 mL
Instructions
Centrifuge and aliquot serum into plastic vial within 2 hours of collection.
Patient Preparation
N/A
Storage
Refrigerated
Transport Temperature
Refrigerated
Specimen Stability
- Room temperature: 28 days
- Refrigerated: 28 days
- Frozen: 28 days
Limitations
Voriconazole metabolism may be altered by coadministration of drugs that metabolically induce or inhibit cytochrome P450 2C19 or by genetic alterations that affect enzyme activity.
Other Acceptable Specimens
N/A
Unacceptable Specimens
Serum from a SST
Order Code
VORIS
EPIC (Premier) Code
LAB6929
Includes
Voriconazole level
CPT Code
80285
Billing Code
N/A
CPT Statement
Methodology
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
FDA Status
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Mayo Clinic Laboratories -- Rochester Superior Drive
3050 Superior Drive NW
Rochester MN, 55901
3050 Superior Drive NW
Rochester MN, 55901
Department
N/A
Reference Range
1.0-5.5 mcg/mL
Setup Schedule / Expected Turnaround Time
1-2 Days, Monday-Sunday
Specimen Collection
Special Instructions
Trough level (ie, immediately before next dose) monitoring is recommended.
Preferred Specimen
2 mL serum from a red top tube
Minimum Volume
0.6 mL
Instructions
Centrifuge and aliquot serum into plastic vial within 2 hours of collection.
Patient Preparation
N/A
Storage
Refrigerated
Transport Temperature
Refrigerated
Specimen Stability
- Room temperature: 28 days
- Refrigerated: 28 days
- Frozen: 28 days
Limitations
Voriconazole metabolism may be altered by coadministration of drugs that metabolically induce or inhibit cytochrome P450 2C19 or by genetic alterations that affect enzyme activity.
Other Acceptable Specimens
N/A
Unacceptable Specimens
Serum from a SST
Result Information
Methodology
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Testing Laboratory
N/A
Reference Range
1.0-5.5 mcg/mL
Setup Schedule / Expected Turnaround Time
1-2 Days, Monday-Sunday