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Neurofilament Light Chain (NFL), Plasma

Test Summary

Neurofilament Light Chain (NfL), Plasma - Neurofilament light (NfL) is an intermediate filament protein found specifically in the neuronal cytoskeleton. It can be released into the extracellular space through axonal degradation, and it has been shown that varying NfL levels are an indicator of neuroaxonal damage, irrespective of the cause, and can therefore be associated with a variety of neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, frontotemporal dementia, or Alzheimer's disease, as well as acute situations such as traumatic brain injury and others. NfL is thus considered a promising biomarker for, disease activity, progression, prognosis, and monitoring effectiveness of therapies. As NfL can be measured in both cerebrospinal fluid (CSF) and blood, it holds great potential for routine clinical use.

Aliases

  • Multiple Sclerosis,Alzheimer,Dementia,Neurodegeneration,MS

Specimen Collection

Special Instructions

N/A

Preferred Specimen

0.7 mL  plasma collected in an EDTA (lavender-top) tube. Room Temperature

Minimum Volume

0.5 mL

Instructions

Draw blood in an EDTA (lavender-top) tube. Invert to mix with preservatives. Centrifuge and transfer plasma to a labeled plastic transport tube.

Patient Preparation

Patients should be cautioned to stop biotin consumption at least 72 hours prior to collection of a sample

Storage

Room Temperature

Transport Temperature

Room Temperature

Specimen Stability

  • Room Temperature: 35 days
  • Refrigerated: 35 days
  • Frozen: 56 days

Limitations

N/A

Other Acceptable Specimens

N/A

Unacceptable Specimens

Hemolysis

Order Code

NFLC

EPIC (Premier) Code

LAB6914

Includes

N/A

CPT Code

  • 83884

Billing Code

  • 670339

CPT Statement

CPT Statement

Methodology

Immunoassay (IA)

FDA Status

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Physician Attestation of Informed Consent

N/A

Testing Laboratory

Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675

Department

Reference Testing

Reference Range

  • <20 years Not established
  • 20-29 years <1.60 pg/mL
  • 30-39 years <2.21 pg/mL
  • 40-49 years <3.21 pg/mL
  • 50-59 years <4.05 pg/mL
  • 60-69 years <12.28 pg/mL
  • 70-79 years <12.52 pg/mL
  • >79 years <28.51 pg/Ml

Setup Schedule / Expected Turnaround Time

Monday, Tuesday - Saturday; Report available: 1 - 3 days

Specimen Collection

Special Instructions

N/A

Preferred Specimen

0.7 mL  plasma collected in an EDTA (lavender-top) tube. Room Temperature

Minimum Volume

0.5 mL

Instructions

Draw blood in an EDTA (lavender-top) tube. Invert to mix with preservatives. Centrifuge and transfer plasma to a labeled plastic transport tube.

Patient Preparation

Patients should be cautioned to stop biotin consumption at least 72 hours prior to collection of a sample

Storage

Room Temperature

Transport Temperature

Room Temperature

Specimen Stability

  • Room Temperature: 35 days
  • Refrigerated: 35 days
  • Frozen: 56 days

Limitations

N/A

Other Acceptable Specimens

N/A

Unacceptable Specimens

Hemolysis

Billing

CPT Code

  • 83884

Billing Code

  • 670339

CPT Statement

CPT Statement

Result Information

Methodology

Immunoassay (IA)

Testing Laboratory

N/A

Reference Range

  • <20 years Not established
  • 20-29 years <1.60 pg/mL
  • 30-39 years <2.21 pg/mL
  • 40-49 years <3.21 pg/mL
  • 50-59 years <4.05 pg/mL
  • 60-69 years <12.28 pg/mL
  • 70-79 years <12.52 pg/mL
  • >79 years <28.51 pg/Ml

Setup Schedule / Expected Turnaround Time

Monday, Tuesday - Saturday; Report available: 1 - 3 days