AD Detect ® Beta-Amyloid 42/40 Ratio, P
Test Summary
Quest AD-Detect® Beta-Amyloid 42/40 Ratio, Plasma - This LC-MS/MS assay measures beta-amyloid 40 (AB40) as well as AB42 in plasma, rather than AB42 alone. This permits the normalization of beta amyloid levels circulating in plasma in different patients. Using the ratio of beta-amyloid 42/beta-amyloid 40, improves sensitivity and specificity for detecting Alzheimer's disease.
Aliases
- ABeta 42,ABeta 40,AB40,AB42,Alzheimer's Disease (AD),AB42/40,AD,ABeta 42/40
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1.2 mL plasma collected in an EDTA (lavender-top) tube. Plasma must be seperated from cells within 1 hour of collection. Frozen
Minimum Volume
0.6 mL
Instructions
Collect blood into an EDTA (lavender-top) tube and mix by inversion 10 times. Centrifuge to separate plasma from cells within 1 hour of collection. Carefully transfer plasma into a polypropylene tube. Do not transfer to conical tube. If unable to centrifuge within 1 hour of collection, store tube on ice.
Patient Preparation
N/A
Storage
Frozen
Transport Temperature
Frozen
Specimen Stability
- Room Temperature: Unacceptable
- Refrigerated: 72 hours Frozen -20° C: 32 days Frozen -70° C: 77 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
- Moderate or gross hemolysis
- Specimen collected in a glass, polystyrene, or polycarbonate tube
Order Code
ADBAR
EPIC (Premier) Code
LAB6918
Includes
ABeta 42, ABeta 40, ABeta 42/40 Ratio
CPT Code
- 82233
- 82234
Billing Code
- 670292
- 670352
CPT Statement
Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Reference Range
- ABeta 42 Not established pg/mL
- ABeta 40 Not established pg/mL
- ABeta 42/40 Ratio ≥0.170
Setup Schedule / Expected Turnaround Time
Monday - Saturday; Report available: 3 - 5 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1.2 mL plasma collected in an EDTA (lavender-top) tube. Plasma must be seperated from cells within 1 hour of collection. Frozen
Minimum Volume
0.6 mL
Instructions
Collect blood into an EDTA (lavender-top) tube and mix by inversion 10 times. Centrifuge to separate plasma from cells within 1 hour of collection. Carefully transfer plasma into a polypropylene tube. Do not transfer to conical tube. If unable to centrifuge within 1 hour of collection, store tube on ice.
Patient Preparation
N/A
Storage
Frozen
Transport Temperature
Frozen
Specimen Stability
- Room Temperature: Unacceptable
- Refrigerated: 72 hours Frozen -20° C: 32 days Frozen -70° C: 77 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
- Moderate or gross hemolysis
- Specimen collected in a glass, polystyrene, or polycarbonate tube
Result Information
Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Testing Laboratory
N/A
Reference Range
- ABeta 42 Not established pg/mL
- ABeta 40 Not established pg/mL
- ABeta 42/40 Ratio ≥0.170
Setup Schedule / Expected Turnaround Time
Monday - Saturday; Report available: 3 - 5 days