Chromosome Analysis, Tissue
Test Summary
Chromosome analysis of products of conception (POC) can detect fetal chromosome abnormalities, which are associated with approximately one-half of all first trimester spontaneous abortions. Chromosome testing on fibroblasts obtained from a tissue biopsy is performed to investigate tissue specific mosaicism not present in blood lymphocytes. Fresh cells from tissue biopsies obtained postmortem may still be suitable for chromosome analysis when the patient's blood is not available or viable. If chromosome analysis is unsuccessful, please contact the laboratory genetic counselor at 1-866-GENEINFO (1-866-436-3463) to discuss the option of adding chromosomal microarray (CMA) testing.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
5 x 5 tissue collected in a sterile container in Hanks', Ringer's solution or culture medium with antibiotics.
Minimum Volume
2 x 3 mm
Instructions
N/A
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room Temperature
Specimen Stability
- Room Temperature = Preferred
- Refrigerated = Acceptable
- Frozen = Unacceptable
Limitations
N/A
Other Acceptable Specimens
Tissue collected in sterile saline
Unacceptable Specimens
Formalin-fixed
Order Code
CHRMST
EPIC (Premier) Code
LAB498
Includes
*** Test may be replaced by Cytogenetics Communication and Chromosome Analysis, Tissue, No Growth ***
CPT Code
- 88233
- 88262
Billing Code
- 670192
- 670193
CPT Statement
Methodology
Karyotype • Microscopy • Tissue Culture
FDA Status
FDA Approved
Physician Attestation of Informed Consent
This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Testing
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Daily; Report available: 15 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
5 x 5 tissue collected in a sterile container in Hanks', Ringer's solution or culture medium with antibiotics.
Minimum Volume
2 x 3 mm
Instructions
N/A
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room Temperature
Specimen Stability
- Room Temperature = Preferred
- Refrigerated = Acceptable
- Frozen = Unacceptable
Limitations
N/A
Other Acceptable Specimens
Tissue collected in sterile saline
Unacceptable Specimens
Formalin-fixed
Result Information
Methodology
Karyotype • Microscopy • Tissue Culture
Testing Laboratory
N/A
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Daily; Report available: 15 days