Acylcarnitine, Plasma
Test Summary
Determining the specific apolipoprotein E (APOE) genotypes in individuals with type III hyperlipoproteinemia. Determining the specific apolipoprotein E (APOE) genotypes that may increase risk for amyloid related imaging abnormalities in individuals being treated for Alzheimer disease with B-amyloid-targeting antibodies. APOE genotyping has been used to assess susceptibility for Alzheimer disease. However, the use of APOE analysis for predictive testing for Alzheimer disease is not currently recommended by the American College of Medical Genetics due to limited clinical utility and poor predictive value.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL frozen plasma collected in sodium heparin (green-top) tube
Minimum Volume
0.5 mL frozen serum
Instructions
Collect blood sample in sodium heparin (green-top) tube. Separate plasma by centrifugation ASAP. Avoid hemolysis. Remove plasma and place in plastic tube. Freeze immediately after separation. Date of birth is required.
Patient Preparation
Patient should be in a well-fed state
Storage
N/A
Transport Temperature
Frozen
Specimen Stability
- Room Temperature = Unacceptable
- Refrigerated = Unacceptable
- Frozen = 28 days
Limitations
A low carnitine level may mask a disease state.
Other Acceptable Specimens
Serum
Unacceptable Specimens
Gross hemolysis • Received room temperature • Received refrigerated
Order Code
ACYLCP
EPIC (Premier) Code
LAB6018
Includes
N/A
CPT Code
- 82017
Billing Code
- 700000
CPT Statement
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Mornings; 3 days a week. Report available: 5 - 6 days.
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL frozen plasma collected in sodium heparin (green-top) tube
Minimum Volume
0.5 mL frozen serum
Instructions
Collect blood sample in sodium heparin (green-top) tube. Separate plasma by centrifugation ASAP. Avoid hemolysis. Remove plasma and place in plastic tube. Freeze immediately after separation. Date of birth is required.
Patient Preparation
Patient should be in a well-fed state
Storage
N/A
Transport Temperature
Frozen
Specimen Stability
- Room Temperature = Unacceptable
- Refrigerated = Unacceptable
- Frozen = 28 days
Limitations
A low carnitine level may mask a disease state.
Other Acceptable Specimens
Serum
Unacceptable Specimens
Gross hemolysis • Received room temperature • Received refrigerated
Result Information
Methodology
Chromatography/Mass Spectrometry
Testing Laboratory
N/A
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Mornings; 3 days a week. Report available: 5 - 6 days.