5-Hydroxyindoleacetic Acid (5-HIAA), Random Urine with Creatinine
Test Summary
Values above 10 mg/24 hrs occur in carcinoid syndrome. Slight elevations also occur in nontropical sprue and after reserpine administration.
Drugs which can interfere with testing due to physiologic response: Acetaminophen, Alpha and Beta Blockers, Atenolol, Bromocriptine, Bronchodilators, Clonidine, Digoxin, Isoniazid, L-Dopa, Labetalol, Methyldopa, Monoamine Oxidase Inhibitors, Nitroglycerin, Sympathomimetic Amines, Phenobarbital, Phenothiazines, Phentolamine, Reserpine, Salicylates, Tricyclic Antidepressants
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
10 mL random urine with 6N HCl submitted in a plastic, screw-cap container
Minimum Volume
5 mL
Instructions
After urine collection, add 6N HCl to maintain a pH below 3.
Urine without preservative is acceptable if pH is below 6 and the sample is shipped frozen.
Record patients age on test request form and urine vial.
Patient Preparation
Patient should avoid food high in indoles: avocado, banana, tomato, plum, walnut, pineapple, and eggplant
Storage
N/A
Transport Temperature
Preserved: Room temperature
Unpreserved: Frozen
Unpreserved: Frozen
Specimen Stability
- Room temperature: 7 days
- Refrigerated: 30 days
- Frozen: 30 days
Limitations
Patients with renal disease may display falsely decreased results. Urinary 5-HIAA is increased in patients with malabsorption disorders who also display a larger concentration of urinary tryptophan metabolites. Urinary 5-HIAA is increased in patients with intestinal obstruction and with some noncarcinoid islet cell tumors. Carcinoid syndrome may not cause elevated results, especially if the patient does not have diarrhea.
Other Acceptable Specimens
Random urine, unpreserved, collected in a sterile screw-cap container
Unacceptable Specimens
pH >3.0 and received unfrozen
Order Code
5HIAAU
EPIC (Premier) Code
LAB3265
Includes
Creatinine
CPT Code
- 82570
- 83497
Billing Code
- 670503
- 670504
CPT Statement
Methodology
High Performance Liquid Chromatography (HPLC) • Electrochemical Detection
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Testing
Reference Range
5-HIAA, Random Urine
Creatinine, Random Urine
| <2 Years | Not established | |
| 2-10 Years | ≤12.0 mg/g creat | |
| >10 Years | ≤10.0 mg/g creat | |
| ≤6 Months | 2-28 mg/dL | |
| 7-11 Months | 2-31 mg/dL | |
| 1-2 Years | 2-110 mg/dL | |
| 3-8 Years | 2-130 mg/dL | |
| 9-12 Years | 2-160 mg/dL | |
| >12 Years Male | 20-320 mg/dL | |
| >12 Years Female | 20-275 mg/dL | |
Setup Schedule / Expected Turnaround Time
Monday - Friday morning; Report available: 2 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
10 mL random urine with 6N HCl submitted in a plastic, screw-cap container
Minimum Volume
5 mL
Instructions
After urine collection, add 6N HCl to maintain a pH below 3.
Urine without preservative is acceptable if pH is below 6 and the sample is shipped frozen.
Record patients age on test request form and urine vial.
Patient Preparation
Patient should avoid food high in indoles: avocado, banana, tomato, plum, walnut, pineapple, and eggplant
Storage
N/A
Transport Temperature
Preserved: Room temperature
Unpreserved: Frozen
Unpreserved: Frozen
Specimen Stability
- Room temperature: 7 days
- Refrigerated: 30 days
- Frozen: 30 days
Limitations
Patients with renal disease may display falsely decreased results. Urinary 5-HIAA is increased in patients with malabsorption disorders who also display a larger concentration of urinary tryptophan metabolites. Urinary 5-HIAA is increased in patients with intestinal obstruction and with some noncarcinoid islet cell tumors. Carcinoid syndrome may not cause elevated results, especially if the patient does not have diarrhea.
Other Acceptable Specimens
Random urine, unpreserved, collected in a sterile screw-cap container
Unacceptable Specimens
pH >3.0 and received unfrozen
Result Information
Methodology
High Performance Liquid Chromatography (HPLC) • Electrochemical Detection
Testing Laboratory
N/A
Reference Range
5-HIAA, Random Urine
Creatinine, Random Urine
| <2 Years | Not established | |
| 2-10 Years | ≤12.0 mg/g creat | |
| >10 Years | ≤10.0 mg/g creat | |
| ≤6 Months | 2-28 mg/dL | |
| 7-11 Months | 2-31 mg/dL | |
| 1-2 Years | 2-110 mg/dL | |
| 3-8 Years | 2-130 mg/dL | |
| 9-12 Years | 2-160 mg/dL | |
| >12 Years Male | 20-320 mg/dL | |
| >12 Years Female | 20-275 mg/dL | |
Setup Schedule / Expected Turnaround Time
Monday - Friday morning; Report available: 2 days