Soluble Liver Antigen (SLA) Autoantibody
Test Summary
Anti-soluble liver antigen antibodies are detected in 10-30% of patients with type 1 autoimmune hepatitis (AIH), but not in patients with type 2 AIH, primary sclerosing cholangitis or primary biliary cirrhosis. The antibody is directed against a UGA suppressor tRNA-associated protein. In some patients with AIH, this antibody may be the only autoantibody detected by current assays.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL serum
Minimum Volume
0.3 mL
Instructions
Centrifuge serum specimens, transfer serum to a sterile, plastic, screw-capped vial(s).
Refrigerate at 2-8°C, and send on refrigerant coolants to the laboratory. If shipping is delayed, freeze at -20°C, or lower (avoid freeze/thaw cycles) and send frozen samples on dry ice.
Refrigerate at 2-8°C, and send on refrigerant coolants to the laboratory. If shipping is delayed, freeze at -20°C, or lower (avoid freeze/thaw cycles) and send frozen samples on dry ice.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: 48 hours
- Refrigerated: 8 days
- Frozen: 28 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
Gross hemolysis • Lipemia
Order Code
SLA
EPIC (Premier) Code
LAB3945
Includes
N/A
CPT Code
- 83520
Billing Code
- 671036
CPT Statement
Methodology
Immunoassay (IA)
FDA Status
FDA Approved
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Testing
Reference Range
| <20.1 U | Negative |
| 20.1-24.9 U | Equivocal |
| ≥25.0 U | Positive |
Setup Schedule / Expected Turnaround Time
Tuesday, Thursday; Report available: 1 day
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1 mL serum
Minimum Volume
0.3 mL
Instructions
Centrifuge serum specimens, transfer serum to a sterile, plastic, screw-capped vial(s).
Refrigerate at 2-8°C, and send on refrigerant coolants to the laboratory. If shipping is delayed, freeze at -20°C, or lower (avoid freeze/thaw cycles) and send frozen samples on dry ice.
Refrigerate at 2-8°C, and send on refrigerant coolants to the laboratory. If shipping is delayed, freeze at -20°C, or lower (avoid freeze/thaw cycles) and send frozen samples on dry ice.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: 48 hours
- Refrigerated: 8 days
- Frozen: 28 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
Gross hemolysis • Lipemia
Result Information
Methodology
Immunoassay (IA)
Testing Laboratory
N/A
Reference Range
| <20.1 U | Negative |
| 20.1-24.9 U | Equivocal |
| ≥25.0 U | Positive |
Setup Schedule / Expected Turnaround Time
Tuesday, Thursday; Report available: 1 day