Porphobilinogen, Quantitative, Random Urine
Test Summary
Urinary Porphobilinogen is the first step in the diagnosis of acute porphyria's such as acute intermittent porphyria (AIP). AIP is an autosomal dominant disorder characterized by deficiency of porphobilinogen deaminase. An acute attack usually includes gastrointestinal disturbance and neuropsychiatric disorders.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
2 mL unpreserved urine collected in a plastic leak-proof container. Protect from light.
Minimum Volume
1 mL
Instructions
Urine should be refrigerated and protected from light.
Whenever possible, the specimen should be collected during an acute episode because porphobilinogen (PBG) may decrease rapidly upon remission. PBG may also degrade when samples are exposed to UV light for extended periods, or are transported at ambient temperature. If an amber collection jug/urine cup is not available, the sample must be protected from light by completely wrapping the container in aluminum foil. PBG is most stable at pH 6-7, but all samples may be sent with or without preservative. All results should be interpreted in the context of clinical findings, relevant history, and other laboratory data.
Whenever possible, the specimen should be collected during an acute episode because porphobilinogen (PBG) may decrease rapidly upon remission. PBG may also degrade when samples are exposed to UV light for extended periods, or are transported at ambient temperature. If an amber collection jug/urine cup is not available, the sample must be protected from light by completely wrapping the container in aluminum foil. PBG is most stable at pH 6-7, but all samples may be sent with or without preservative. All results should be interpreted in the context of clinical findings, relevant history, and other laboratory data.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: Unacceptable
- Refrigerated: 7 days
- Frozen: 30 days
Limitations
N/A
Other Acceptable Specimens
Random clean-catch urine collected with 0.5g sodium carbonate (Na2CO3) per 100 mL of sample
Unacceptable Specimens
Not protected from light
Order Code
PORQNU
EPIC (Premier) Code
LAB3651
Includes
N/A
CPT Code
- 84110
Billing Code
- 670431
CPT Statement
Methodology
Chromatography/Mass Spectrometry
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Testing
Reference Range
| ≤17 Years | <0.36 mg/g creat |
| ≥18 Years | <0.22 mg/g creat |
Setup Schedule / Expected Turnaround Time
Tuesday, Thursday, Saturday; Report available: 4 - 7 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
2 mL unpreserved urine collected in a plastic leak-proof container. Protect from light.
Minimum Volume
1 mL
Instructions
Urine should be refrigerated and protected from light.
Whenever possible, the specimen should be collected during an acute episode because porphobilinogen (PBG) may decrease rapidly upon remission. PBG may also degrade when samples are exposed to UV light for extended periods, or are transported at ambient temperature. If an amber collection jug/urine cup is not available, the sample must be protected from light by completely wrapping the container in aluminum foil. PBG is most stable at pH 6-7, but all samples may be sent with or without preservative. All results should be interpreted in the context of clinical findings, relevant history, and other laboratory data.
Whenever possible, the specimen should be collected during an acute episode because porphobilinogen (PBG) may decrease rapidly upon remission. PBG may also degrade when samples are exposed to UV light for extended periods, or are transported at ambient temperature. If an amber collection jug/urine cup is not available, the sample must be protected from light by completely wrapping the container in aluminum foil. PBG is most stable at pH 6-7, but all samples may be sent with or without preservative. All results should be interpreted in the context of clinical findings, relevant history, and other laboratory data.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: Unacceptable
- Refrigerated: 7 days
- Frozen: 30 days
Limitations
N/A
Other Acceptable Specimens
Random clean-catch urine collected with 0.5g sodium carbonate (Na2CO3) per 100 mL of sample
Unacceptable Specimens
Not protected from light
Result Information
Methodology
Chromatography/Mass Spectrometry
Testing Laboratory
N/A
Reference Range
| ≤17 Years | <0.36 mg/g creat |
| ≥18 Years | <0.22 mg/g creat |
Setup Schedule / Expected Turnaround Time
Tuesday, Thursday, Saturday; Report available: 4 - 7 days