Porphyrins, Fractionated, Quantitative, 24-Hour Urine
Test Summary
Porphyria is a group of distinct disorders characterized by the abnormal accumulation of porphyrins or porphyrin precursors. Porphyrin Fractionation of Urine is useful in diagnosing porphyrin cutanea tarda, hereditary coproporphyria, and variegate porphyria.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
2 mL urine from a 24-hour urine collected in a 5 g sodium carbonate container or no preservative container - protected from light
Minimum Volume
1 mL
Instructions
2 mL 24-hour urine in 5 g sodium carbonate container or no preservative container 24-hour urine collected with 5 grams of sodium carbonate, refrigerated and protected from light during collection is preferred.
Collection with no preservative is acceptable, if properly refrigerated and light protected. 24-hour total volume must be provided on the test request form.
Collection with no preservative is acceptable, if properly refrigerated and light protected. 24-hour total volume must be provided on the test request form.
Patient Preparation
N/A
Storage
Transport tube - protected from light
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: Unacceptable
- Refrigerated: 7 days
- Frozen: 30 days
Limitations
N/A
Other Acceptable Specimens
No preservative - See Collection Instructions
Unacceptable Specimens
Received room temperature • Not protected from light • pH <4.0
Order Code
PORPHF
EPIC (Premier) Code
LAB330
Includes
Coproporphyrin I, Coproporphyrin III, Heptacarboxyporphyrin, Hexacarboxyporphyrin, Pentacarboxyporphyrin, Uroporphyrin I, Uroporphyrin III, Total Porphyrins
CPT code 81050 may be added at an additional charge for volume measurement
CPT code 81050 may be added at an additional charge for volume measurement
CPT Code
- 84120
Billing Code
- 670430
- 500002
CPT Statement
Methodology
High Performance Liquid Chromatography (HPLC)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Testing
Reference Range
| Uroporphyrin I | 4.1-22.4 mcg/24 h |
| Uroporphyrin III | 0.7-7.4 mcg/24 h |
| Heptacarboxyporphyrin | ≤3.3 mcg/24 h |
| Hexacarboxyporphyrin | ≤10 mcg/24 h |
| Pentacarboxyporphyrin | ≤4.6 mcg/24 h |
| Coproporphyrin I | 7.1-48.7 mcg/24 h |
| Coproporphyrin III | 11.0-148.5 mcg/24 h |
| Total Porphyrins | 35.0-210.7 mcg/24 h |
Setup Schedule / Expected Turnaround Time
Tuesday - Saturday; Report available: 1 - 5 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
2 mL urine from a 24-hour urine collected in a 5 g sodium carbonate container or no preservative container - protected from light
Minimum Volume
1 mL
Instructions
2 mL 24-hour urine in 5 g sodium carbonate container or no preservative container 24-hour urine collected with 5 grams of sodium carbonate, refrigerated and protected from light during collection is preferred.
Collection with no preservative is acceptable, if properly refrigerated and light protected. 24-hour total volume must be provided on the test request form.
Collection with no preservative is acceptable, if properly refrigerated and light protected. 24-hour total volume must be provided on the test request form.
Patient Preparation
N/A
Storage
Transport tube - protected from light
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: Unacceptable
- Refrigerated: 7 days
- Frozen: 30 days
Limitations
N/A
Other Acceptable Specimens
No preservative - See Collection Instructions
Unacceptable Specimens
Received room temperature • Not protected from light • pH <4.0
Result Information
Methodology
High Performance Liquid Chromatography (HPLC)
Testing Laboratory
N/A
Reference Range
| Uroporphyrin I | 4.1-22.4 mcg/24 h |
| Uroporphyrin III | 0.7-7.4 mcg/24 h |
| Heptacarboxyporphyrin | ≤3.3 mcg/24 h |
| Hexacarboxyporphyrin | ≤10 mcg/24 h |
| Pentacarboxyporphyrin | ≤4.6 mcg/24 h |
| Coproporphyrin I | 7.1-48.7 mcg/24 h |
| Coproporphyrin III | 11.0-148.5 mcg/24 h |
| Total Porphyrins | 35.0-210.7 mcg/24 h |
Setup Schedule / Expected Turnaround Time
Tuesday - Saturday; Report available: 1 - 5 days