Porphyrins, Fractionated, Quantitative, Random Urine
Order Code:
PORPFR
Test Summary
Porphyria is a group of distinct disorders, characterized by the abnormal accumulation of porphyrins or porphyrin precursors. Porphyrin fractionation of urine is useful in diagnosing porphyrin cutanea tarda, hereditary coproporphyria, and variegate porphyria.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
2 mL random urine in 5 grams sodium carbonate (Na2CO3) container - protected from light
Minimum Volume
1.5 mL
Instructions
Random urine collected with 5 grams of sodium carbonate, refrigerated, and protected from light during collection is preferred. Collection with no preservative is acceptable, if properly refrigerated and light protected.
Patient Preparation
N/A
Storage
Transport Temperature
Refrigerated (cold packs) - ok to thaw
Specimen Stability
- Room temperature: Unacceptable
- Refrigerated: 7 days
- Frozen: 30 days
Limitations
N/A
Other Acceptable Specimens
Unpreserved random urine submitted in a plastic leak-proof container (light protected) • Unpreserved catheterized or first void clean catch or random clean catch urine (light protected)
Unacceptable Specimens
Received room temperature • Samples not protected from light • Samples with a pH <4.0
Order Code
PORPFR
EPIC (Premier) Code
LAB329
Includes
Coproporphyrin I, Coproporphyrin III, Heptacarboxyporphyrin, Hexacarboxyporphyrin, Pentacarboxyporphyrin, Uroporphyrin I, Uroporphyrin III, Total Porphyrins
CPT Code
- 84120
Billing Code
- 670429
CPT Statement
Methodology
High Performance Liquid Chromatography (HPLC)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Testing
Reference Range
| Uroporphyrin I | 3.6-21.1 mcg/g creat |
| Uroporphyrin III | ≤5.6 mcg/g creat |
| Heptacarboxyporphyrin | ≤3.4 mcg/g creat |
| Hexacarboxyporphyrin | ≤6.3 mcg/g creat |
| Pentacarboxyporphyrin | ≤4.1 mcg/g creat |
| Coproporphyrin I | 6.5-33.2 mcg/g creat |
| Coproporphyrin III | 4.8-88.6 mcg/g creat |
| Total Porphyrins | 27.0-153.6 mcg/g creat |
Setup Schedule / Expected Turnaround Time
Sunday, Tuesday - Friday; Report available: 5 - 7 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
2 mL random urine in 5 grams sodium carbonate (Na2CO3) container - protected from light
Minimum Volume
1.5 mL
Instructions
Random urine collected with 5 grams of sodium carbonate, refrigerated, and protected from light during collection is preferred. Collection with no preservative is acceptable, if properly refrigerated and light protected.
Patient Preparation
N/A
Storage
Transport Temperature
Refrigerated (cold packs) - ok to thaw
Specimen Stability
- Room temperature: Unacceptable
- Refrigerated: 7 days
- Frozen: 30 days
Limitations
N/A
Other Acceptable Specimens
Unpreserved random urine submitted in a plastic leak-proof container (light protected) • Unpreserved catheterized or first void clean catch or random clean catch urine (light protected)
Unacceptable Specimens
Received room temperature • Samples not protected from light • Samples with a pH <4.0
Result Information
Methodology
High Performance Liquid Chromatography (HPLC)
Testing Laboratory
N/A
Reference Range
| Uroporphyrin I | 3.6-21.1 mcg/g creat |
| Uroporphyrin III | ≤5.6 mcg/g creat |
| Heptacarboxyporphyrin | ≤3.4 mcg/g creat |
| Hexacarboxyporphyrin | ≤6.3 mcg/g creat |
| Pentacarboxyporphyrin | ≤4.1 mcg/g creat |
| Coproporphyrin I | 6.5-33.2 mcg/g creat |
| Coproporphyrin III | 4.8-88.6 mcg/g creat |
| Total Porphyrins | 27.0-153.6 mcg/g creat |
Setup Schedule / Expected Turnaround Time
Sunday, Tuesday - Friday; Report available: 5 - 7 days