Porphyrins, Fractionated, Plasma
Test Summary
Porphyria is a group of distinct disorders characterized by the abnormal accumulation of porphyrins or porphyrin precursors. Porphyrin fractionation of plasma is useful in diagnosing certain types of porphyria's and excluding porphyria's in patients with chronic renal failure suspected of having a porphyria.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
2 mL plasma collected in a sodium heparin (green-top) tube - light protected
Minimum Volume
0.6 mL
Instructions
Collect blood sample with foil-wrapped green-top tube. Separate plasma by centrifugation. Avoid hemolysis. Remove plasma to a light-protected tube. Freeze immediately after separation.
Patient Preparation
N/A
Storage
Plastic screw-cap vial, protected from light
Transport Temperature
Frozen
Specimen Stability
- Room temperature: 8 hours
- Refrigerated: 8 hours
- Frozen: 90 days
Limitations
N/A
Other Acceptable Specimens
Plasma collected in an EDTA (lavender-top) tube - light protected • Serum collected in a red-top tube (no gel) - light protected
Unacceptable Specimens
Hemolysis • Received room temperature • Received refrigerated • Not protected from light • Serum Separator Tube (SST®)
Order Code
PORPFP
EPIC (Premier) Code
LAB3578
Includes
Uroporphyrin, Heptacarboxyporphyrin, Hexacarboxyporphyrin, Pentacarboxyporphyrin, Coproporphyrin, Protoporphyrin, Total Porphyrins
CPT Code
- 82542
Billing Code
- 670428
CPT Statement
Methodology
High Performance Liquid Chromatography (HPLC)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Testing
Reference Range
| Uroporphyrin | ≤0.2 mcg/L |
| Heptacarboxyporphyrin | ≤0.2 mcg/L |
| Hexacarboxyporphyrin | ≤0.3 mcg/L |
| Pentacarboxyporphyrin | ≤0.4 mcg/L |
| Coproporphyrin | ≤0.8 mcg/L |
| Protoporphyrin | 0.4-4.8 mcg/L |
| Total Porphyrins | 1.0-5.6 mcg/L |
Setup Schedule / Expected Turnaround Time
Sunday, Wedensday; Report available: 5 - 10 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
2 mL plasma collected in a sodium heparin (green-top) tube - light protected
Minimum Volume
0.6 mL
Instructions
Collect blood sample with foil-wrapped green-top tube. Separate plasma by centrifugation. Avoid hemolysis. Remove plasma to a light-protected tube. Freeze immediately after separation.
Patient Preparation
N/A
Storage
Plastic screw-cap vial, protected from light
Transport Temperature
Frozen
Specimen Stability
- Room temperature: 8 hours
- Refrigerated: 8 hours
- Frozen: 90 days
Limitations
N/A
Other Acceptable Specimens
Plasma collected in an EDTA (lavender-top) tube - light protected • Serum collected in a red-top tube (no gel) - light protected
Unacceptable Specimens
Hemolysis • Received room temperature • Received refrigerated • Not protected from light • Serum Separator Tube (SST®)
Result Information
Methodology
High Performance Liquid Chromatography (HPLC)
Testing Laboratory
N/A
Reference Range
| Uroporphyrin | ≤0.2 mcg/L |
| Heptacarboxyporphyrin | ≤0.2 mcg/L |
| Hexacarboxyporphyrin | ≤0.3 mcg/L |
| Pentacarboxyporphyrin | ≤0.4 mcg/L |
| Coproporphyrin | ≤0.8 mcg/L |
| Protoporphyrin | 0.4-4.8 mcg/L |
| Total Porphyrins | 1.0-5.6 mcg/L |
Setup Schedule / Expected Turnaround Time
Sunday, Wedensday; Report available: 5 - 10 days