Paraneoplastic Antibody Evaluation with Reflex to Titer and Line Blot, Basic
Test Summary
Detection of antineuronal autoantibodies aids the diagnosis of paraneoplastic syndromes and autoimmune encephalopathies and related conditions. Identification of specific antineuronal autoantibodies may direct evaluation for underlying often occult malignancy. Characterization of autoantibody specificity may allow syndromic classification and assist in diagnosis and management. Antineuronal antibodies are detected and characterized based on indirect immunofluorescence staining pattern on multiple neuronal, non-neuronal tissues, and transformed substrate cells, and radioimmunoassay's, and western blot analysis.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
6 mL frozen serum
Minimum Volume
3 mL
Instructions
N/A
Patient Preparation
N/A
Storage
Transport tube
Transport Temperature
Frozen
Specimen Stability
- Room temperature: 48 hours
- Refrigerated: 48 hours
- Frozen 21 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
Gross hemolysis • Grossly lipemic • Grossly icteric
Order Code
PARNEO
EPIC (Premier) Code
LAB6456
Includes
If Paraneoplastic Antibody Screen, IFA, Basic is positive for ANNA3, then ANNA-3 Ab, IFA Titer will be performed at an additional charge (CPT code(s) 86256).
If Paraneoplastic Antibody Screen, IFA, Basic is positive for PCA-2, then PCA-2 Ab, IFA Titer will be performed at an additional charge (CPT code(s) 86256).
If Paraneoplastic Antibody Screen, IFA, Basic suggests NMO-5-IgG, then specific CBA-IFA assay will be performed at an additional charge (CPT code(s) 86255).
If Paraneoplastic Antibody Screen, IFA, Basic suggests AMPA-R, GABA-B-R, or NMDA-R, then specific CBA-IFA assay will be performed at an additional charge (CPT code(s) 86255 x4).
If Paraneoplastic Antibody Screen, IFA, Basic is positive or indeterminate, then Paraneoplastic Antibody, LB, Basic will be performed at an additional charge (CPT code(s) 84182 x5, 86341).
If Anti-Striated Muscle Antibody Screen is positive, then Anti-Striated Muscle Antibody Titer will be performed at an additional charge (CPT code(s) 86256).
If AChR Binding Antibody is positive (≥0.50) or Equivocal (0.31-0.49), then Paraneoplastic Antibody, LB, Basic and AChR Modulating Antibody will both be performed at additional charges (CPT code(s) 83519).
If Paraneoplastic Antibody Screen, IFA, Basic is positive for PCA-2, then PCA-2 Ab, IFA Titer will be performed at an additional charge (CPT code(s) 86256).
If Paraneoplastic Antibody Screen, IFA, Basic suggests NMO-5-IgG, then specific CBA-IFA assay will be performed at an additional charge (CPT code(s) 86255).
If Paraneoplastic Antibody Screen, IFA, Basic suggests AMPA-R, GABA-B-R, or NMDA-R, then specific CBA-IFA assay will be performed at an additional charge (CPT code(s) 86255 x4).
If Paraneoplastic Antibody Screen, IFA, Basic is positive or indeterminate, then Paraneoplastic Antibody, LB, Basic will be performed at an additional charge (CPT code(s) 84182 x5, 86341).
If Anti-Striated Muscle Antibody Screen is positive, then Anti-Striated Muscle Antibody Titer will be performed at an additional charge (CPT code(s) 86256).
If AChR Binding Antibody is positive (≥0.50) or Equivocal (0.31-0.49), then Paraneoplastic Antibody, LB, Basic and AChR Modulating Antibody will both be performed at additional charges (CPT code(s) 83519).
CPT Code
- 86255 (x10)
- 83519 (x3)
- 86596 (x2)
Billing Code
- 670965
- 670966
- 670967
CPT Statement
Methodology
See individual tests
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Testing
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Varies; Report available: 4 - 13 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
6 mL frozen serum
Minimum Volume
3 mL
Instructions
N/A
Patient Preparation
N/A
Storage
Transport tube
Transport Temperature
Frozen
Specimen Stability
- Room temperature: 48 hours
- Refrigerated: 48 hours
- Frozen 21 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
Gross hemolysis • Grossly lipemic • Grossly icteric
Billing
CPT Code
- 86255 (x10)
- 83519 (x3)
- 86596 (x2)
Billing Code
- 670965
- 670966
- 670967
CPT Statement
Result Information
Methodology
See individual tests
Testing Laboratory
N/A
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Varies; Report available: 4 - 13 days