Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G
Test Summary
Plasma plasminogen activator inhibitor, PAI-1 is a major inhibitor of fibrinolysis. The 4G variant (AF386492.2:g.837del) in the PAI-1 (Serpine 1) gene promoter region is associated with an increase in the level of PAI-1 in plasma. Increased levels of PAI-1 in plasma may increase the risk for arterial and venous thrombosis, myocardial infarction, and progression of atherosclerosis and also recurrent spontaneous abortion.
Aliases
- N/A
Specimen Collection
Special Instructions
N/A
Preferred Specimen
5 mL whole blood collected in an EDTA (lavender-top) tube
Minimum Volume
3 mL
Instructions
Whole blood: Normal phlebotomy procedure. Specimen stability is crucial. Store and ship room temperature immediately. Do not freeze.
Forward tissue and extracted DNA specimens immediately to the Molecular Genetics Laboratory; do not hold.
Forward tissue and extracted DNA specimens immediately to the Molecular Genetics Laboratory; do not hold.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 8 days
- Refrigerated: 8 days
- Frozen: Unacceptable
Limitations
N/A
Other Acceptable Specimens
Whole blood collected in: Sodium heparin (green-top) tube, ACD solution A or B (yellow-top) tube, or lithium heparin (green-top) tube
Unacceptable Specimens
N/A
Order Code
PAI1X
EPIC (Premier) Code
LAB3159
Includes
N/A
CPT Code
- 81400
Billing Code
- 670864
CPT Statement
Methodology
Polymerase Chain Reaction and Detection
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Testing
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Wednesday, Saturday; Report available: 7 - 11 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
5 mL whole blood collected in an EDTA (lavender-top) tube
Minimum Volume
3 mL
Instructions
Whole blood: Normal phlebotomy procedure. Specimen stability is crucial. Store and ship room temperature immediately. Do not freeze.
Forward tissue and extracted DNA specimens immediately to the Molecular Genetics Laboratory; do not hold.
Forward tissue and extracted DNA specimens immediately to the Molecular Genetics Laboratory; do not hold.
Patient Preparation
N/A
Storage
N/A
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 8 days
- Refrigerated: 8 days
- Frozen: Unacceptable
Limitations
N/A
Other Acceptable Specimens
Whole blood collected in: Sodium heparin (green-top) tube, ACD solution A or B (yellow-top) tube, or lithium heparin (green-top) tube
Unacceptable Specimens
N/A
Result Information
Methodology
Polymerase Chain Reaction and Detection
Testing Laboratory
N/A
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Wednesday, Saturday; Report available: 7 - 11 days