Hu, Yo, and Ri Antibodies with Reflex to Titers and Western Blot
Test Summary
Hu anti-neuronal nuclear antibody (anti-Hu) is found in 5-10% of patients with small cell carcinoma of the lung. Purkinje cell (Yo) antibody is found in patients with paraneoplastic cerebellar degeneration and is associated with breast, ovarian, and other gynecologic cancers. Some patients with ovarian cancer have low titers of Yo antibodies in the absence of cerebellar degeneration. Anti-Hu antibodies are associated with paraneoplastic encephalomyelitis and sensory neuropathy. Anti-Ri antibody can be detected in patients with paraneoplastic opsoclonus/myoclonus syndrome. Neoplasms most often associated with anti-Ri include breast cancer, small cell lung cancer, and gynecological cancers.
Aliases
- Paraneoplastic Syndrome AB Panel
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1.5 mL serum
Minimum Volume
0.6 mL
Instructions
N/A
Patient Preparation
Overnight fasting is preferred
Storage
Transport tube
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 7 days
- Refrigerated: 14 days
- Frozen: 21 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
N/A
Order Code
NEURAB
EPIC (Premier) Code
LAB5509
Includes
Neuronal Nuclear (Hu) Antibody with Reflex to Titer and Western Blot; Neuronal Nuclear (Yo) Antibody with Reflex to Titer and Western Blot; Neuronal Nuclear (Ri) Antibody with Reflex to Titer and Western Blot
If Hu Antibody Screen, IFA is positive, Hu Antibody, Western Blot will be performed at an additional charge (CPT code(s): 84181).
If Hu Antibody, Western Blot is positive, Hu Antibody, Titer will be performed at an additional charge (CPT code(s): 86256).
If Yo Antibody Screen, IFA is positive, Yo Antibody, Western Blot will be performed at an additional charge (CPT code(s): 84181).
If Yo Antibody, Western Blot is positive, Yo Antibody, Titer will be performed at an additional charge (CPT code(s): 86256).
If Ri Antibody Screen, IFA is positive, Ri Antibody, Western Blot will be performed at an additional charge (CPT code(s): 84181).
If Ri Antibody, Western Blot is positive, Ri Antibody, Titer will be performed at an additional charge (CPT code(s): 86256).
If Hu Antibody Screen, IFA is positive, Hu Antibody, Western Blot will be performed at an additional charge (CPT code(s): 84181).
If Hu Antibody, Western Blot is positive, Hu Antibody, Titer will be performed at an additional charge (CPT code(s): 86256).
If Yo Antibody Screen, IFA is positive, Yo Antibody, Western Blot will be performed at an additional charge (CPT code(s): 84181).
If Yo Antibody, Western Blot is positive, Yo Antibody, Titer will be performed at an additional charge (CPT code(s): 86256).
If Ri Antibody Screen, IFA is positive, Ri Antibody, Western Blot will be performed at an additional charge (CPT code(s): 84181).
If Ri Antibody, Western Blot is positive, Ri Antibody, Titer will be performed at an additional charge (CPT code(s): 86256).
CPT Code
- 86255 (x3)
Billing Code
- 670349
CPT Statement
Methodology
Immunofluorescence Assay (IFA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Physician Attestation of Informed Consent
N/A
Testing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675
33608 Ortega Highway
San Juan Capistrano CA, 92675
Department
Reference Testing
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Monday, Wednesday, Friday; Report available: 3 days
Specimen Collection
Special Instructions
N/A
Preferred Specimen
1.5 mL serum
Minimum Volume
0.6 mL
Instructions
N/A
Patient Preparation
Overnight fasting is preferred
Storage
Transport tube
Transport Temperature
Room temperature
Specimen Stability
- Room temperature: 7 days
- Refrigerated: 14 days
- Frozen: 21 days
Limitations
N/A
Other Acceptable Specimens
N/A
Unacceptable Specimens
N/A
Result Information
Methodology
Immunofluorescence Assay (IFA)
Testing Laboratory
N/A
Reference Range
See Laboratory Report
Setup Schedule / Expected Turnaround Time
Monday, Wednesday, Friday; Report available: 3 days