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Test Directory Myelin Oligodendrocyte Glycoprotein (MOG) Antibody with Reflex to Titer, Serum

Myelin Oligodendrocyte Glycoprotein (MOG) Antibody with Reflex to Titer, Serum

Test Summary

Neuromyelitis optica (NMO) is an inflammatory disorder predominantly affecting the optic nerves and spinal cord. Limited forms of disease including isolated optic neuritis, brainstem encephalitis and longitudinal extensive transverse myelitis (LETM) or acute disseminated encephalomyelitis (ADEM) have been referred to as NMO spectrum disorder (NMOSD). The majority of individuals with NMO and many with NMOSD have antibodies against aquaporin 4 (AQP4). MOG antibodies have been reported without AQP4 antibodies in individuals with NMO and other non-multiple sclerosis demyelinating diseases. The presence of MOG antibodies in AQP4 antibody negative individuals can help differentiate between multiple sclerosis (MS) and non-MS demyelinating diseases and aid in clinical management decisions.

Aliases

Specimen Collection

Special Instructions

N/A

Preferred Specimen

2 mL serum

Minimum Volume

0.5 mL

Instructions

N/A

Patient Preparation

N/A

Storage

N/A

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 21 days

Limitations

N/A

Other Acceptable Specimens

N/A

Unacceptable Specimens

Serum Separator Tube (SST) • Visible particulate matter

Order Code

MOGAB

EPIC (Premier) Code

LAB6369

Includes

If the MOG Antibody screen is positive, then a semi-quantitative titer will be performed at an additional charge (CPT code(s): 86362).

CPT Code

86362

Billing Code

670962

CPT Statement

Methodology

Cell-based Immunofluorescence Assay

FDA Status

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Physician Attestation of Informed Consent

N/A

Testing Laboratory

Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano CA, 92675

Department

Reference Testing

Reference Range

MOG Ab CBA, Serum	Negative
MOG Ab Titer, Serum	<1:10 titer

Setup Schedule / Expected Turnaround Time

Wednesday morning; Report available: 4 days